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Biological functions of folic acid (FA) have been reported in various cells to include synthesis and repair of DNA. We have shown that over-dosage of FA causes blood haemolysis, leading to progressive anaemia. It is reported that 200 -400 µg/ml of FA increases the size of blood cells within 2h of treatment leading to abnormal cell division and necrosis. This observation suggests early cellular aging or senescence. We hypothesized that FA may play a vital role in cellular senescence. Kidneydoi:10.13034/cysj-2014-024 fatcat:yeg4p464srhpvo3gpfcc3oxbwi