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Urinary detection of corticosteroid in topical treatment of skin disease by 19F MRS
2019
Magnetic Resonance Materials in Physics, Biology and Medicine
Objective To investigate if it was feasible to quantify the renal excretion of topically applied corticosteroids by 19 F MRS. Materials and methods Five participants, one healthy and four with skin diseases, were treated with ointment containing betamethasone 17-valerate. Urine samples were collected for up to 87 h after the initial application. A sample of ointment mixed with urine served as a study control. Organic fractions were obtained after sample freeze drying, and resolved in deuterated
doi:10.1007/s10334-018-00734-y
fatcat:ffaj6orhffhjtm6oxugo24uoem