PATERNAL CONTRIBUTION TO EMBRYONIC DEATH

M. W. H. BISHOP
1964 Reproduction  
This essay advances the theory that an unsuspectedly large part of embryonic death is attributable to genetic causes. The genetic factors involved are not necessarily inherited by the parents, indeed the majority probably arise de novo in each parent generation and some are likely to arise in the definitive gametes. The theory seeks to account for the nature of unexplained fertility differences between males, and of idiogenic infertility, and of some of the decline in fertility that is
more » ... d with age. It suggests that a considerable part of embryonic death is unavoidable and should be regarded as a normal way of eliminating unfit genotypes in each generation.
doi:10.1530/jrf.0.0070383 pmid:14180731 fatcat:z6vol2cgknbjvg2angiohgarqa