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Physalis alkekengi has a large history of herbal use because of its pharmacological characteristics.The objectives of this study are to investigate effects of Physalis alkekengi extract on the structure of testis, its sperm parametic data, hormone levels(progesterone) and expression of cAMP-responsive element modulator(CREM) of adult rats. Physalis alkekengi extract was administered to adult male wistar rats (n=8) for 56 consecutive days (150 mg/kg/body weight/day). At the end of the treatmentfatcat:4eke32ca3nbvphe6zphxfsypuq