Efek Proteksi Otak Erythropoietin

Iwan Fuadi, Tatang Bisri
2015 Jurnal Neuroanestesi Indonesia  
In this study endothelial cell dysfunction in male white mice were examined. Endothelial cell dysfunction is indicated by low levels of NO and can cause hypertension. Endothelial cell dysfunction was induced by administering NaCl 3%. In this study, purified extract of Toona sureni leaves 5, 10, and 20 mg / kg BW were administered orally for 21 days along with NaCl. NO Serum levels were observed as the study parameter. The results showed that the administration of purified extract of T sureni
more » ... ract of T sureni leaves can protect endothelial cells dysfunction induced by NaCl 3%, which marked by increasing of male white mice nitrogen monoxide levels. In addition, it shows significantly different <0 05compared to levels of NO positive control mice (administered NaCl 3% only). Moreoveer, The administration of purified extract of surian leaves did not affect the ratio of heart, kidney and liver weight of the on the study animal (p> 0.05). ABSTRAK: Pada penelitian ini diteliti disfungsi sel endotel pada mencit putih jantan. Disfungsi sel endotel ditunjukkan dengan rendahnya kadar NO dan dapat menyebabkan hipertensi. Disfungsi sel endotel diinduksi dengan pemberian NaCl 3 %. Pada penelitian ini digunakan dosis ekstrak terpurifikasi daun Toona sureni (5, 10, 20) mg/kg BB yang diberikan secara oral selama 21 hari bersamaan dengan NaCl. Para meter yang diamati adalah kadar NO dalam serum. Hasil penelitian menunjukan bahwa pemberian ekstrak terpurifikasi daun T sureni terbukti dapat memproteksi disfungsi sel endotel diinduksi NaCl 3 %, ditandai dengan meningkatkan kadar nitrogen monoksida mencit putih jantan dibandingkan kadar NO mencit kontrol positif (hanya diberi NaCl 3 %) dan berbeda nyata p < 0,05. Pemberian ekstrak terpurifikasi daun surian tidak mempengaruhi rasio berat organ jantung, ginjal dan hati, hewan uji (p > 0,05).
doi:10.24244/jni.vol4no2.93 fatcat:pxaaf54objgutlrjkibztfrlty