Functional innovation from changes in protein domains and their combinations

Jonathan G Lees, Natalie L Dawson, Ian Sillitoe, Christine A Orengo
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="" style="color: black;">Current Opinion in Structural Biology</a> </i> &nbsp;
Domains are the functional building blocks of proteins. In this work we discuss how domains can contribute to the evolution of new functions. Domains themselves can evolve through various mechanisms, altering their intrinsic function. Domains can also facilitate functional innovations by combining with other domains to make novel proteins. We discuss the mechanisms by which domain and domain combinations support functional innovations. We highlight interesting examples where changes in domain combination promote changes at the domain level.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1016/</a> <a target="_blank" rel="external noopener" href="">pmid:27309309</a> <a target="_blank" rel="external noopener" href="">fatcat:vykx2i6uabfazpwv4oozsyxnle</a> </span>
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