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To present a study protocol to compare glucose and reflexology in pain relief in neonate intensive care during arterial punctures. A randomized, controlled, double-blind clinical trial protocol will be carried out at a teaching hospital maternity, with30 newborns admitted to neonate intensive care who are to undergo blood collection by arterial puncture. They will be randomly assigned to a control group (25% glucose) or an intervention group (foot reflexology). The primary outcome will bedoi:10.1590/1983-1447.2022.20220103.en pmid:36449836 fatcat:eqin4dvmvbhrhncohcvrwc33ky