To present a study protocol to compare glucose and reflexology in pain relief in neonate intensive care during arterial punctures. A randomized, controlled, double-blind clinical trial protocol will be carried out at a teaching hospital maternity, with30 newborns admitted to neonate intensive care who are to undergo blood collection by arterial puncture. They will be randomly assigned to a control group (25% glucose) or an intervention group (foot reflexology). The primary outcome will be

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... e pain scores during and after arterial puncture. Secondary outcomes will be crying time and variation in neonates' vital signs during and after the arterial puncture procedure. Registration number RBR-639bff. The results of this trial will provide new insights into the most appropriate intervention for the relief of neonate pain during painful procedures.