Cellular Microparticles as a Marker for Cerebral Vasospasm in Spontaneous Subarachnoid Hemorrhage

P. Lackner, A. Dietmann, R. Beer, M. Fischer, G. Broessner, R. Helbok, J. Marxgut, B. Pfausler, E. Schmutzhard
2010 Stroke  
and Purpose-Spontaneous subarachnoid hemorrhage (SAH) still has a high risk for poor outcome that is frequently attributable to symptomatic cerebral vasospasm (CVS). We hypothesize that cellular microparticles (MP) play a role in the pathogenesis of CVS and may serve as biomarkers for CVS. Methods-In 20 consecutive SAH patients, endothelial, leukocyte, platelet, and erythrocyte MP were measured during 15 days after ictus. CVS was detected by transcranial Doppler sonography. Twenty matched
more » ... wenty matched volunteers served as healthy controls. Results-Endothelial, leukocyte, and erythrocyte MP were elevated in SAH patients compared to healthy controls. CD105 ϩ and CD62e ϩ endothelial MP were significantly higher in SAH patients with Doppler sonographic CVS. CD105 ϩ endothelial MP were especially increased on the days of Doppler sonographic CVS onset. In patients experiencing cerebral infarction attributable to vasospasm, CD41 ϩ platelet MP were elevated in addition to endothelial MP. CD41 ϩ platelet MP were significantly higher in patients with any level of disability (modified Rankin Scale score Ն1) compared to those who made a full recovery (modified Rankin Scale scoreϭ0) on discharge from hospital. Conclusion-Endothelial MP were elevated in patients with SAH. This elevation coincided with the occurrence of Doppler sonographic CVS and therefore could be a novel biomarker for CVS. Platelet MP might be involved in the pathogenesis of cerebral infarction attributable to vasospasm, resulting in neurological morbidity. (Stroke. 2010;41:2353-2357.) Key Words: delayed cerebral ischemia Ⅲ endothelial microparticles Ⅲ subarachnoid hemorrhage A neurysmal subarachnoid hemorrhage (SAH) is still associ-
doi:10.1161/strokeaha.110.584995 pmid:20814009 fatcat:xcahmqtcmbblngocdo2nvrq3we