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Genetics has long been confused by the pleiotropic mutational effects associated with even clearly-annotated genes. To understand such genetic effects, we here examine HAP4, a well-studied transcription factor in Saccharomyces cerevisiae that forms a tetramer with HAP2, HAP3, and HAP5. Deletion of HAP4 results in highly pleiotropic gene expression responses, some of which are clustered in related cellular processes (clustered effects) while most are distributed randomly across diverse cellulardoi:10.1101/688358 fatcat:jo43lzdqbzckfaqxzykt72hqzm