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wKinMut: An integrated tool for the analysis and interpretation of mutations in human protein kinases
2013
BMC Bioinformatics
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Acknowledgements The authors thank the members of the Structural Biology and Biocomputing Programme (CNIO), especially A. Rausell, D. Juan, I. Ezkurdia and T. ...
Pons, for interesting discussion and comments on this manuscript. ...
Implementation wKinMut represents the first resource to provide an integrated tool for the analysis and interpretation of the consequences of mutations in the protein kinase superfamily. ...
doi:10.1186/1471-2105-14-345
pmid:24289158
pmcid:PMC3879071
fatcat:wblb72yq5nelnlseujbysgukgy
wKinMut-2: Identification and Interpretation of Pathogenic Variants in Human Protein Kinases
2015
Human Mutation
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interpretation of the consequences 32 of human protein kinase variation. ...
However, this heterogeneous information is often scattered across 30 different sources, which makes the integrative analysis complex and laborious. 31 wKinMut-2 constitutes a solution to facilitate the ...
of wKinMut-2 help to identify and interpret 570 pathogenic variants in human protein kinases. 571 572 TABLES 573
function in Weka. ...
doi:10.1002/humu.22914
pmid:26443060
fatcat:is4f4opuencpraavflxspgctuy
Interpretation of the Consequences of Mutations in Protein Kinases: Combined Use of Bioinformatics and Text Mining
2012
Frontiers in Physiology
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Finally, we will discuss how text mining approaches constitute a powerful tool for the interpretation of the consequences of mutations in the context of disease genome analysis with particular focus on ...
In this article, we will review the possibilities and limitations of current computational methods for the prediction of the pathogenicity of mutations in the protein kinase superfamily. ...
wKinMut 2 to help in the interpretation of mutations in the protein kinase superfamily. ...
doi:10.3389/fphys.2012.00323
pmid:23055974
pmcid:PMC3449330
fatcat:i2qqkuh4nfde3pxeknjbvgpfpe
Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics
2012
Genome Medicine
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Acknowledgements The work in the group of AV related to this review is supported by grants from the ENCODE Project (U54 HG0004555), eTOX (Grant 115002, Innovative Medicines Initiative) and Consolider E-Science ...
(CSD2007-00050), the Instituto de Salud Carlos III COMBIOMED (RD07/0067/0014) and the Spanish Ministry of Science and Innovation (BIO2007-66855). ...
The identification of binding sites and active sites in proteins is therefore an important aid to interpreting the effects of mutations. ...
doi:10.1186/gm362
pmid:22839973
pmcid:PMC3580417
fatcat:2t5baj5uovdw7p72ohvorkufdy