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tGRAP, the G-protein coupled receptors mutant database
2002
Nucleic Acids Research
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The searchable mutant database tGRAP (previously called tinyGRAP) at the University of Tromsø contains data on mutated G-protein coupled receptors (GPCRs). ...
The current version of the tGRAP mutant database (tGRAP.uit.no, release 10, April 2001) contains around 10 500 mutants extracted from almost 1400 research papers containing mutant data on five families ...
INTRODUCTION G-protein coupled receptors (GPCRs) are important targets for therapeutic drugs. Therefore, their structural and functional features have been extensively characterized. ...
doi:10.1093/nar/30.1.361
pmid:11752337
pmcid:PMC99129
fatcat:t3udnvmrfbfq3k3glbslstobwi
Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions
2003
Journal of Biological Chemistry
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G protein-coupled receptor (GPCR) activation mediated by ligand-induced structural reorganization of its helices is poorly understood. ...
Both were functionally critical, causing constitutive G protein activation of the mutants and rapid loss of regeneration after photobleaching. ...
), the March of Dimes (Grant FY03-93), and the Welch Foundation (Grant R01-EY07981). ...
doi:10.1074/jbc.m312671200
pmid:14660595
fatcat:fspdjtvfc5bnldgaeyp3peqxiq
Conserved Motifs in Somatostatin, D2-dopamine, and α2B-Adrenergic Receptors for Inhibiting the Na-H Exchanger, NHE1
2003
Journal of Biological Chemistry
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We identified conserved motifs within intracellular domains 2 and 3 of selective subtypes of several G protein-coupled receptor families that confer coupling to the Na-H exchanger, NHE1. ...
These findings indicate that motifs shared by different subfamilies of G protein-coupled receptors, but not necessarily by receptor subtypes within a subfamily, can confer coupling to a common effector ...
a change in G protein coupling. ...
doi:10.1074/jbc.m212315200
pmid:12566440
fatcat:742uhbuts5gtjaczq7encby7bm
Automatic Extraction of Protein Point Mutations Using a Graph Bigram Association
2007
PLoS Computational Biology
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Our method was tested on 589 articles describing point mutations from the G protein-coupled receptor (GPCR), tyrosine kinase, and ion channel protein families. ...
Our algorithm uses a graph-based bigram traversal to identify these relevant associations and exploits the Swiss-Prot protein database to verify this information. ...
FH conceived of the study and contributed to the methods. FEC helped conceive the study and helped draft the manuscript. Funding. ...
doi:10.1371/journal.pcbi.0030016
pmid:17274683
pmcid:PMC1794323
fatcat:5t5jlanvpfemponujhzlon3zvu
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base
2007
BMC Bioinformatics
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Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological processes and therefore represent key ...
Commentary Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base Lucy Skrabanek1'2, M arta M urcia1, Michel Bouvier3, Lakshmi Devi4, Susan R George5, M artin J Lohse6 ...
A or protein kinase C, indicat ing coupling to the G aq pathway. ...
doi:10.1186/1471-2105-8-177
pmid:17537266
pmcid:PMC1904246
fatcat:nqs47qalkrgkxfxobvmakai4um
Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer
2003
FEBS Letters
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A subset of G protein-coupled receptors, one of the largest families involved in cellular signaling, rod and cone opsins are involved in phototransduction in photoreceptor cells. ...
Extensive sequence data and structural sampling of expressed proteins from di¡erent species lead to the idea that entire molecules or speci¢c domain folds belong to large superfamilies of proteins. ...
(RPB) to the Department of Ophthalmology at the University of Washington, and a grant from the E.K. Bishop Foundation. K.P. is an RPB Senior Investigator. We thank Drs. ...
doi:10.1016/s0014-5793(03)01152-9
pmid:14630336
pmcid:PMC1468034
fatcat:d2w5op5dpjh3bfeamzrdhshivq
The Fourth Paradigm – Data-Intensive Scientific Discovery
[chapter]
2012
Communications in Computer and Information Science
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The F o u r T H Data-In t e n s I v e scIen t I f I c DIs c o v e r y P a r a d i g m MiCroSoF T reSe arCH REDMOND, WASHINGTON ...
Acknowledgments My thanks to the participants at the April 24, 2009, Buckland-Lynch-Larsen "Friday Seminar" on information access at the University of California, Berkeley, School of Information for a ...
very helpful discussion on a draft of this material. to all the contributors to this book for sharing their visions within the Fourth Paradigm. ...
doi:10.1007/978-3-642-33299-9_1
fatcat:etue636ubrandga5corvkx3d7u