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tGRAP, the G-protein coupled receptors mutant database

O. Edvardsen
2002 Nucleic Acids Research  
The searchable mutant database tGRAP (previously called tinyGRAP) at the University of Tromsø contains data on mutated G-protein coupled receptors (GPCRs).  ...  The current version of the tGRAP mutant database (, release 10, April 2001) contains around 10 500 mutants extracted from almost 1400 research papers containing mutant data on five families  ...  INTRODUCTION G-protein coupled receptors (GPCRs) are important targets for therapeutic drugs. Therefore, their structural and functional features have been extensively characterized.  ... 
doi:10.1093/nar/30.1.361 pmid:11752337 pmcid:PMC99129 fatcat:t3udnvmrfbfq3k3glbslstobwi

Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions

Srinivasan Madabushi, Alecia K. Gross, Anne Philippi, Elaine C. Meng, Theodore G. Wensel, Olivier Lichtarge
2003 Journal of Biological Chemistry  
G protein-coupled receptor (GPCR) activation mediated by ligand-induced structural reorganization of its helices is poorly understood.  ...  Both were functionally critical, causing constitutive G protein activation of the mutants and rapid loss of regeneration after photobleaching.  ...  ), the March of Dimes (Grant FY03-93), and the Welch Foundation (Grant R01-EY07981).  ... 
doi:10.1074/jbc.m312671200 pmid:14660595 fatcat:fspdjtvfc5bnldgaeyp3peqxiq

Conserved Motifs in Somatostatin, D2-dopamine, and α2B-Adrenergic Receptors for Inhibiting the Na-H Exchanger, NHE1

Chin-Yu Lin, Madhulika G. Varma, Anita Joubel, Srinivasan Madabushi, Olivier Lichtarge, Diane L. Barber
2003 Journal of Biological Chemistry  
We identified conserved motifs within intracellular domains 2 and 3 of selective subtypes of several G protein-coupled receptor families that confer coupling to the Na-H exchanger, NHE1.  ...  These findings indicate that motifs shared by different subfamilies of G protein-coupled receptors, but not necessarily by receptor subtypes within a subfamily, can confer coupling to a common effector  ...  a change in G protein coupling.  ... 
doi:10.1074/jbc.m212315200 pmid:12566440 fatcat:742uhbuts5gtjaczq7encby7bm

Automatic Extraction of Protein Point Mutations Using a Graph Bigram Association

Lawrence C. Lee, Florence Horn, Fred E. Cohen
2007 PLoS Computational Biology  
Our method was tested on 589 articles describing point mutations from the G protein-coupled receptor (GPCR), tyrosine kinase, and ion channel protein families.  ...  Our algorithm uses a graph-based bigram traversal to identify these relevant associations and exploits the Swiss-Prot protein database to verify this information.  ...  FH conceived of the study and contributed to the methods. FEC helped conceive the study and helped draft the manuscript. Funding.  ... 
doi:10.1371/journal.pcbi.0030016 pmid:17274683 pmcid:PMC1794323 fatcat:5t5jlanvpfemponujhzlon3zvu

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

Lucy Skrabanek, Marta Murcia, Michel Bouvier, Lakshmi Devi, Susan R George, Martin J Lohse, Graeme Milligan, Richard Neubig, Krzysztof Palczewski, Marc Parmentier, Jean-Philippe Pin, Gerrit Vriend (+3 others)
2007 BMC Bioinformatics  
Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological processes and therefore represent key  ...  Commentary Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base Lucy Skrabanek1'2, M arta M urcia1, Michel Bouvier3, Lakshmi Devi4, Susan R George5, M artin J Lohse6  ...  A or protein kinase C, indicat ing coupling to the G aq pathway.  ... 
doi:10.1186/1471-2105-8-177 pmid:17537266 pmcid:PMC1904246 fatcat:nqs47qalkrgkxfxobvmakai4um

Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer

David C. Teller, Ronald E. Stenkamp, Krzysztof Palczewski
2003 FEBS Letters  
A subset of G protein-coupled receptors, one of the largest families involved in cellular signaling, rod and cone opsins are involved in phototransduction in photoreceptor cells.  ...  Extensive sequence data and structural sampling of expressed proteins from di¡erent species lead to the idea that entire molecules or speci¢c domain folds belong to large superfamilies of proteins.  ...  (RPB) to the Department of Ophthalmology at the University of Washington, and a grant from the E.K. Bishop Foundation. K.P. is an RPB Senior Investigator. We thank Drs.  ... 
doi:10.1016/s0014-5793(03)01152-9 pmid:14630336 pmcid:PMC1468034 fatcat:d2w5op5dpjh3bfeamzrdhshivq

The Fourth Paradigm – Data-Intensive Scientific Discovery [chapter]

Tony Hey
2012 Communications in Computer and Information Science  
The F o u r T H Data-In t e n s I v e scIen t I f I c DIs c o v e r y P a r a d i g m MiCroSoF T reSe arCH REDMOND, WASHINGTON  ...  Acknowledgments My thanks to the participants at the April 24, 2009, Buckland-Lynch-Larsen "Friday Seminar" on information access at the University of California, Berkeley, School of Information for a  ...  very helpful discussion on a draft of this material. to all the contributors to this book for sharing their visions within the Fourth Paradigm.  ... 
doi:10.1007/978-3-642-33299-9_1 fatcat:etue636ubrandga5corvkx3d7u