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tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: A 7T magnetic resonance spectroscopy study

Soyoung Kim, Mary C. Stephenson, Peter G. Morris, Stephen R. Jackson
2014 NeuroImage  
We used ultra-high-field (7 T) magnetic resonance spectroscopy (MRS), together with a robotic force adaptation and de-adaptation task, to investigate whether tDCS-induced alterations in GABA and Glutamate  ...  Importantly, we show that the magnitude of tDCS-induced alterations in GABA concentration within motor cortex predicts individual differences in both motor learning and motor memory on the robotic force  ...  Acknowledgments This work was supported by MRC grant G0901321 awarded to PGM and SRJ and by a grant from the James Tudor Foundation to SRJ and PGM.  ... 
doi:10.1016/j.neuroimage.2014.05.070 pmid:24904994 pmcid:PMC4121086 fatcat:aftamdtu6vc6xmjspgbvj6j2jq

Age-related decline in cortical inhibitory tone strengthens motor memory [article]

Pierre Petitet, Gershon Spitz, Heidi Johansen-Berg, Jacinta O'Shea
2020 bioRxiv   pre-print
As predicted, older age was associated with lower γ-amino butyric acid (GABA), the inhibitory neurotransmitter, and stronger adaptation memory.  ...  Ageing causes a natural decline in cortical inhibitory tone and associated functional decrements.  ...  Three Tesla magnetic resonance spectroscopy was used to quantify neurochemical concentration in left sensorimotor cortex (labelled "M1"), and in a control region of occipital cortex (labelled "V1"; see  ... 
doi:10.1101/2020.12.03.410308 fatcat:vl3e6aj3xjhcpopvi35ptcwh4i

Causal explanation of individual differences in human sensorimotor memory formation [article]

Pierre Petitet, Jill X O'Reilly, Ana M Goncalves, Piergiorgio Salvan, Shigeru Kitazawa, Heidi Johansen-Berg, Jacinta O'Shea
2018 bioRxiv   pre-print
Inter-individual variance in the stimulation-induced E:I increase predicted the computational change, which predicted the memory gain.  ...  Sensorimotor cortex mediates the formation of adaptation memory. Individuals differ in the rate at which they acquire, retain, and generalize adaptation.  ...  Two participants Figure 7 : 7 Figure 7: Magnetic Resonance Spectroscopy data. A. Example raw spectroscopy spectrum and LC model fit from one participant.  ... 
doi:10.1101/255091 fatcat:hvhg2lwfmrcchb2ecycz5vdakm

Tuning noninvasive brain stimulation with MRI to cope with intersubject variability

Annegret Habich, Santiago Canals, Stefan Klöppel
2016 Current Opinion in Neurology  
In this context, MRI techniques, such as magnetic resonance spectroscopy and functional MRI, emerged as valuable tools for the qualitative assessment of baseline states and induced changes.  ...  and rehabilitative predictions.  ...  Kim S, Stephenson MC, Morris PG, Jackson SR. tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: a 7 T magnetic resonance spectroscopy study  ... 
doi:10.1097/wco.0000000000000353 pmid:27257946 fatcat:xv2xxhtkandatbi7aipywpvcxi

No Effect of Anodal tDCS on Verbal Episodic Memory Performance and Neurotransmitter Levels in Young and Elderly Participants

Annegret Habich, Johannes Slotboom, Jessica Peter, Roland Wiest, Stefan Klöppel
2020 Neural Plasticity  
Using MEGA-PRESS edited magnetic resonance spectroscopy (MRS), Glx and GABA levels were measured in the left DLPFC before and after the stimulation period.  ...  Glutamatergic metabolites (Glx) and γ-aminobutyric acid (GABA) are involved in learning and memory processes and can be influenced with tDCS; wherefore, they present themselves as potential biomarkers  ...  for the primary motor cortex [108] .  ... 
doi:10.1155/2020/8896791 pmid:33029128 pmcid:PMC7528151 fatcat:ovzpcofyzfcoxehfskcgcdx3jy

Neural changes associated with cerebellar tDCS studied using MR spectroscopy

Roya Jalali, Alimul Chowdhury, Martin Wilson, R. Chris Miall, Joseph M. Galea
2018 Experimental Brain Research  
Anodal cerebellar transcranial direct current stimulation (tDCS) is known to enhance motor learning, and therefore, has been suggested to hold promise as a therapeutic intervention.  ...  Although cerebellar tDCS did not affect visuomotor adaptation, surprisingly cerebellar tDCS increased motor memory retention with this being strongly correlated with a decrease in cerebellar glutamate  ...  reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s00221-018-5170-1 pmid:29404634 pmcid:PMC5887008 fatcat:bkmm62hgpnbynawgtsptzclumu

Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review

Chang‐Hoon Choi, Elene Iordanishvili, N. Jon Shah, Ferdinand Binkofski
2021 Human Brain Mapping  
on neurometabolites using magnetic resonance spectroscopy (MRS).  ...  In this way, a well-defined modulation of brain energy and excitability can be achieved using a dedicated tDCS protocol to a predetermined brain region.  ...  tDCS compared to baseline or sham Kim et al. (2014) Investigation of the effects of tDCS on GABA and glutamate in motor cortex and their role in motor learning and motor memory Independent t  ... 
doi:10.1002/hbm.25388 pmid:33634527 pmcid:PMC8090777 fatcat:lovi5nxxabc4nhhgbnrduhcvbu

Noninvasive Brain Stimulation in Traumatic Brain Injury

Asli Demirtas-Tatlidede, Andrew M. Vahabzadeh-Hagh, Montserrat Bernabeu, Jose M. Tormos, Alvaro Pascual-Leone
2012 The journal of head trauma rehabilitation  
We cover transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), low-level laser therapy (LLLT) and transcranial doppler sonography (TCD) techniques.  ...  While the number of clinical trials employing noninvasive brain stimulation continues to increase in a variety of medication-resistant neurological and psychiatric diseases, studies evaluating their diagnostic  ...  In rats, TBI induces long-lasting working memory deficits associated with increased GABA levels for as long as 1-month post-TBI and administration of GABA antagonists restores memory function, suggesting  ... 
doi:10.1097/htr.0b013e318217df55 pmid:21691215 pmcid:PMC3342413 fatcat:ixgbcg4gzbdlxgkhpmzpvicvmq

Cognitive functions and underlying parameters of human brain physiology are associated with chronotype

Mohammad Ali Salehinejad, Miles Wischnewski, Elham Ghanavati, Mohsen Mosayebi-Samani, Min-Fang Kuo, Michael A. Nitsche
2021 Nature Communications  
We monitor motor cortical excitability, brain stimulation-induced neuroplasticity, and examine motor learning and cognitive functions at circadian-preferred and non-preferred times of day in 32 individuals  ...  Motor learning and cognitive performance (working memory, and attention) along with their electrophysiological components are significantly enhanced at the circadian-preferred, compared to the non-preferred  ...  A.N. is supported by a grant from the German Ministry of Research and Education (GCBS grant 01EE1403C). We appreciate Dr. Fatemeh Yavari, Dr. Asif Jamil, and Mr.  ... 
doi:10.1038/s41467-021-24885-0 fatcat:3cujjltycnftlh5r2k3eumhuni

Cognitive functions and respective parameters of human brain physiology are chronotype-dependent [article]

Mohammad Ali Salehinejad, Miles Wischnewski, Elham Ghanavati, Mohsen Mosayebi-Samani, Min-Fang Kuo, Michael A Nitsche
2021 bioRxiv   pre-print
We monitored motor cortical excitability, brain stimulation-induced neuroplasticity, and examined motor learning and cognitive functions at circadian-preferred and non-preferred times of day in 32 individuals  ...  Motor learning and cognitive performance (working memory, and attention) along with their electrophysiological components were significantly enhanced at the circadian-preferred, compared to the non-preferred  ...  Furthermore, evidence from magnetic resonance spectroscopy shows a learning-specific reduction of GABA concentration in the motor cortex during motor learning 42 .  ... 
doi:10.1101/2021.06.08.447543 fatcat:2cj2ix6sojcavgz4p4zn3bwqvi

Induced sensorimotor cortex plasticity remediates chronic treatment-resistant visual neglect

Jacinta O'Shea, Patrice Revol, Helena Cousijn, Jamie Near, Pierre Petitet, Sophie Jacquin-Courtois, Heidi Johansen-Berg, Gilles Rode, Yves Rossetti
2017 eLife  
Here we show that tonic disinhibition of left motor cortex during prism adaptation enhances consolidation, stabilizing both sensorimotor and cognitive prism after-effects.  ...  This can improve left neglect, but the benefit of a single session is transient (~1 day).  ...  Acknowledgements We thank Masud Husain, Chris Kennard and Glyn Humphreys for helpful comments on the manuscript and Jill X O'Reilly for assistance with figures. Additional information  ... 
doi:10.7554/elife.26602 pmid:28893377 pmcid:PMC5595432 fatcat:c7szojzkbvbidnybmjfij47x6e

The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference

Renée S. Koolschijn, Uzay E. Emir, Alexandros C. Pantelides, Hamed Nili, Timothy E.J. Behrens, Helen C. Barron
2019 Neuron  
When we reduce the concentration of neocortical GABA using trans-cranial direct current stimulation (tDCS), neocortical memory interference increases in proportion to the reduction in GABA, which in turn  ...  The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations of context-dependent memories  ...  We note that in this study we used tDCS as a tool to induce variability in the concentration of GABA in aLOC, which our MRS measures show was successfully achieved.  ... 
doi:10.1016/j.neuron.2018.11.042 pmid:30581011 pmcid:PMC6560047 fatcat:nmmum4wivrdj5cpo2c4f3sksxq

High-intensity Interval Exercise Promotes Motor Cortex Disinhibition and Early Motor Skill Consolidation

Ellen L. Stavrinos, James P. Coxon
2017 Journal of Cognitive Neuroscience  
the primary motor cortex.  ...  ■ Gamma-aminobutyric acid (GABA) inhibition shapes motor cortex output, gates synaptic plasticity in the form of long-term potentiation, and plays an important role in motor learning.  ...  Acknowledgments We are grateful to Nigel Rogasch for comments on the manuscript; Karrin Kuyumcian, Chris Alarcón, and Kim Le for their assistance with data collection and analysis; and the staff at the  ... 
doi:10.1162/jocn_a_01078 pmid:27897671 fatcat:ma6bxpptwbdcpfcgzh6dbqagm4

A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia

Meng di Hou, Viviana Santoro, Andrea Biondi, Sukhi S. Shergill, Isabella Premoli
2021 Journal of Psychiatry & Neuroscience  
Transcranial magnetic stimulation can be combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) to evaluate the excitatory and inhibitory functions of the cerebral cortex in a standardized  ...  The aim of this review was to provide a comprehensive overview of TMS-EMG and TMS-EEG research in schizophrenia, focused on excitation or inhibition, connectivity, motor cortical plasticity and the effect  ...  A systematic review of prospective proton studies96,130 demonstrated that antipsychotic treatment might magnetic resonance spectroscopy studies indicated an effect have changed  ... 
doi:10.1503/jpn.210006 pmid:34933940 pmcid:PMC8695525 fatcat:pjmjs6vt7fatznlqxbznq6hkey

Imaging Developmental and Interventional Plasticity Following Perinatal Stroke

Brandon T Craig, Alicia Hilderley, Adam Kirton, Helen L Carlson
2020 Canadian Journal of Neurological Sciences  
Magnetic resonance imaging (MRI) has revolutionized our understanding of developmental neuroplasticity following early injury, quantifying volumetric, structural, functional, and metabolic compensatory  ...  localizing function, resting state functional imaging for characterizing functional connectomes, and spectroscopy examining neurometabolic changes.  ...  Magnetic Resonance Spectroscopy Magnetic resonance spectroscopy (MRS) quantifies neurometabolite concentrations within a brain region of interest (i.e., an MRS voxel).  ... 
doi:10.1017/cjn.2020.166 pmid:32727626 fatcat:o4inwbmxdzgidfq4pjkjpq4joq
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