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sAOP: linking chemical stressors to adverse outcomes pathway networks

2019 Bioinformatics  
With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP).  ...  Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization.  ...  Acknowledgement We would like to acknowledge Catherine Bjerre Collin's help on the revision of English. Funding  ... 
doi:10.1093/bioinformatics/btz570 pmid:31329252 fatcat:7o62r4h3sncqfkbksve2iyivw4

AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development

Florence Jornod, Thomas Jaylet, Ludek Blaha, Denis Sarigiannis, Luc Tamisier, Karine Audouze, Jonathan Wren
2021 Bioinformatics  
Motivation Adverse Outcome Pathways (AOPs) are a conceptual framework developed to support the use of alternative toxicology approaches in the risk assessment.  ...  levels of biology, to the ultimate health or ecotoxicological adverse outcome.  ...  Acknowledgements The authors would like to acknowledge Inserm and the Université de Paris for supporting the work.  ... 
doi:10.1093/bioinformatics/btab750 pmid:34718414 pmcid:PMC8796376 fatcat:mzxb4vs3gvcv7es36vylghslsm

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve, Doug Crump, Natàlia Garcia-Reyero, Markus Hecker, Thomas H. Hutchinson, Carlie A. LaLone, Brigitte Landesmann, Teresa Lettieri, Sharon Munn, Malgorzata Nepelska, Mary Ann Ottinger, Lucia Vergauwen (+1 others)
2014 Toxicological Sciences  
An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of  ...  a biological system and an adverse outcome at a level of biological organization of regulatory relevance.  ...  ACKNOWLEDGMENTS The content of this paper is the result of an international expert workshop on Advancing Adverse Outcome Pathways (AOPs) for Integrated Toxicology and Regulatory Applications.  ... 
doi:10.1093/toxsci/kfu199 pmid:25466378 pmcid:PMC4318923 fatcat:glrsczc2m5ccdkkphwalowlque

AOP4EUpest: Mapping of pesticides in Adverse Outcome Pathways using a text mining tool

Florence Jornod, Marylène Rugard, Luc Tamisier, Xavier Coumoul, Helle R Andersen, Robert Barouki, Karine Audouze, Jonathan Wren
2020 Bioinformatics  
This allowed us to decipher multiple links between the studied substances and molecular initiating events (MIE), key events (KE) and adverse outcomes (AO).  ...  Adverse Outcome Pathways (AOP) consist in linear representations of mechanistic perturbations at different levels of the biological organization.  ...  Acknowledgements The authors would like to acknowledge HBM4EU, Inserm and the Université de Paris for supporting the work.  ... 
doi:10.1093/bioinformatics/btaa545 pmid:32467965 pmcid:PMC7520043 fatcat:rrckkj2civcgfalzlkhz5retqi

Application of the adverse outcome pathway framework to predict the toxicity of chemicals in the semiconductor manufacturing industry

Kyung-Taek Rim
2021 Molecular & Cellular Toxicology  
To solve current issues using big data, solve current issues related to the semiconductor and electronics industry, I tried to establish the data for each toxicity mechanism for adverse outcome pathway  ...  I believe that a strategy is needed to expand the target organization for each chemical by linking with activities, such as work environment measurement, and cooperating with screening items and methods  ...  Acknowledgements This study was supported by the Korean Occupational Safety and Health Agency (Ulsan, Republic of Korea), the Ministry of Employment and Labor (Sejong, Republic of Korea), and a Grant-in Aid for chemical  ... 
doi:10.1007/s13273-021-00139-4 pmid:33968152 pmcid:PMC8097676 fatcat:6rbn6j4xnnfwrjqcdn6nahwrza

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

Ksenia J. Groh, Raquel N. Carvalho, James K. Chipman, Nancy D. Denslow, Marlies Halder, Cheryl A. Murphy, Dick Roelofs, Alexandra Rolaki, Kristin Schirmer, Karen H. Watanabe
2015 Chemosphere  
h i g h l i g h t s AOP development can improve understanding and predicting chronic toxicity outcomes. Chemical-and site-specific risk assessment requires extension of the AOP framework.  ...  can serve as a venue for integration of knowledge derived from various sources, including empirical data as well as molecular, quantitative and evolutionary-based models describing species responses to  ...  Outcome Pathways (AOPs) for Integrated Toxicology and Regulatory Applications, where the presented work has been initiated.  ... 
doi:10.1016/j.chemosphere.2014.09.068 pmid:25439131 fatcat:ou5slaiourhgzfxjozyetvpewu

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

Richard A. Becker, Gerald T. Ankley, Stephen W. Edwards, Sean W. Kennedy, Igor Linkov, Bette Meek, Magdalini Sachana, Helmut Segner, Bart Van Der Burg, Daniel L. Villeneuve, Haruna Watanabe, Tara S. Barton-Maclaren
2015 Regulatory toxicology and pharmacology  
ultimately, using adverse outcome pathways (AOPs) for various regulatory applications.  ...  Keywords: Adverse outcome pathway Weight of evidence Mode of action Bradford-Hill considerations a b s t r a c t Systematic consideration of scientific support is a critical element in developing and,  ...  Quantitative Adverse Outcome Pathways for Regulatory Applications. <https://aopkb.org/ saop/workshops/somma.html>. Petersen, K., Tollefsen, K.E., 2012.  ... 
doi:10.1016/j.yrtph.2015.04.004 pmid:25863193 fatcat:7lkkycd5bramlfvixejoi27dru

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

Sean W Kennedy, Haruna Watanabe, Richard A Becker, Igor Linkov, Daniel L Villeneuve, Tara S Barton-Maclaren, Helmut Segner, Magdalini Sachana, Gerald T Ankley, Bette Meek, Bart Van Der Burg, Stephen W Edwards
2015
ultimately, using adverse outcome pathways (AOPs) for various regulatory applications.  ...  Keywords: Adverse outcome pathway Weight of evidence Mode of action Bradford-Hill considerations a b s t r a c t Systematic consideration of scientific support is a critical element in developing and,  ...  Quantitative Adverse Outcome Pathways for Regulatory Applications. <https://aopkb.org/ saop/workshops/somma.html>. Petersen, K., Tollefsen, K.E., 2012.  ... 
doi:10.7892/boris.79785 fatcat:ewfoqnncl5a4dograkgovxjuz4