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p13CMFA: Parsimonious 13C metabolic flux analysis

Carles Foguet, Anusha Jayaraman, Silvia Marin, Vitaly A. Selivanov, Pablo Moreno, Ramon Messeguer, Pedro de Atauri, Marta Cascante, Vassily Hatzimanikatis
2019 PLoS Computational Biology  
Such data can be integrated using 13C Metabolic Flux Analysis (13C MFA) to provide quantitative metabolic maps of flux distributions.  ...  Here we present parsimonious 13C MFA (p13CMFA), an approach that runs a secondary optimization in the 13C MFA solution space to identify the solution that minimizes the total reaction flux.  ...  There are two main model-based approaches to quantifying metabolic fluxes, Flux Balance Analysis (FBA) and 13 C Metabolic Flux Analysis ( 13 C MFA).  ... 
doi:10.1371/journal.pcbi.1007310 pmid:31490922 pmcid:PMC6750616 fatcat:qapv63zsqbhdho63ggoel2rvam