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p-medicine: A Medical Informatics Platform for Integrated Large Scale Heterogeneous Patient Data

J Marés, L Shamardin, G Weiler, A Anguita, S Sfakianakis, E Neri, S J Zasada, N Graf, P V Coveney
2014 AMIA Annual Symposium Proceedings  
Secure access to patient data is becoming of increasing importance, as medical informatics grows in significance, to both assist with population health studies, and patient specific medicine in support  ...  In this paper we present our solution: an easy to use distributed informatics platform embedding a state of the art data warehouse incorporating a secure pseudonymisation system protecting access to personal  ...  Acknowledgements The work reported here has been funded in part by the EU FP7 p-medicine (no FP7-ICT-2009-270089) project.  ... 
pmid:25954394 pmcid:PMC4419910 fatcat:ngqg4zfy2jekrjc64oknjlatyy

Towards an interoperable information infrastructure providing decision support for genomic medicine

Matthias Samwald, Holger Stenzhorn, Michel Dumontier, M Scott Marshall, Joanne Luciano, Klaus-Peter Adlassnig
2011 Studies in Health Technology and Informatics  
Here we describe our work and future visions around the creation of a distributed infrastructure for pharmacogenetic data and medical decision support, based on industry standards such as the Web Ontology  ...  Genomic medicine, in which medical decisions are refined by genetic information of particular patients, is becoming increasingly important.  ...  the deployment of automated clinical reminders based on patient characteristics and, ultimately, improving the quality of treatments.  ... 
pmid:21893735 fatcat:v5vvyj6jwndrlmf46rchf6idxm

Participatory Aspects of ICT Infrastructures for Cancer Management [chapter]

Haridimos Kondylakis, Lefteris Koumakis, Ketti Mazzocco, Manolis Tsiknakis, Kostas Marias
2019 P5 eHealth: An Agenda for the Health Technologies of the Future  
Lessons Learnt The patient health records, and the diversity of data sources comprising these, make imperative the development of easy-to-use, standardized health informatics platforms. p-Medicine was  ...  Patients as users of p-medicine can interact with the p-medicine environment via IEmS (Kondylakis et al. 2012 ), a collaborative environment for patient empowerment.  ... 
doi:10.1007/978-3-030-27994-3_6 fatcat:qgur5hwzbzcmxm4svgwcns35gm

Pulling the Strands Together: MEGA Steps to Drive European Genomics and Personalised Medicine

Denis Horgan, Mario Romao, Rob Hastings
2017 Biomedicine Hub  
A number of large scale genome sequencing initiatives have been launched in the last few years to try and capitalise on this potential.  ...  The availability of genetic data from a large number of individuals increases the ability to investigate questions across many rare and common diseases and in different populations, and also provides more  ...  Many of the tools produced through the p-medicine project will have direct utility for MEGA, which will support the validation of p-medicine tools as well as providing data and aggregated expertise to  ... 
doi:10.1159/000481300 pmid:31988947 pmcid:PMC6945953 fatcat:dn66jws4rfdfpipvgcrrkc6xia

Smart Recommendation Services in Support of Patient Empowerment and Personalized Medicine [chapter]

Haridimos Kondylakis, Lefteris Koumakis, Manolis Tsiknakis, Kostas Marias, Eirini Genitsaridi, Gabriella Pravettoni, Alessandra Gorini, Ketti Mazzocco
2013 Smart Innovation, Systems and Technologies  
Their efforts, and those of the contributors, will provide the reader with a view of the current state of the field and serve as a roadmap for future research.  ...  Last, but not least, we are grateful to the Springer staff for their excellent work. Piraeus, Greece George A. Tsihrintzis Piraeus, Greece Maria Virvou Adelaide, Australia Lakhmi C. Jain vii  ...  Conclusion In this Chapter we argue that the integration of psychological and personal variables into multi-scale data systems containing heterogeneous data from a patient will greatly improve the predictive  ... 
doi:10.1007/978-3-319-00375-7_4 fatcat:c3aqzd4mkvfkhfcv5u2lgp74gm

Towards an environment for data mining based analysis processes in bioinformatics and personalized medicine

Dennis Wegener, Simona Rossi, Francesca Buffa, Mauro Delorenzi, Stefan Rüping
2013 Network Modeling Analysis in Health Informatics and Bioinformatics  
In this paper, we present the challenges for data mining based analysis in bio-and medical informatics and our approach towards a data mining environment addressing these requirements in the p-medicine  ...  The p-medicine consortium (http://www.p-medicine.eu) is creating a biomedical platform to facilitate the translation from current practice to a predictive, personalized, preventive, participatory and psycho-cognitive  ...  Building blocks for the data mining environment We identified a set of building blocks that can serve as basis for the p-medicine data mining environment: -Reusing available components: a method for the  ... 
doi:10.1007/s13721-013-0022-1 dblp:journals/netmahib/WegenerRBDR13 fatcat:xnr6jsiko5ff5px2mxbk7ckwfy

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics [article]

Mahnoor Naseer Gondal, Safee Ullah Chaudhary
2021 bioRxiv   pre-print
(iii) associated simulation software for development of personalized cancer therapeutics, and (iv) translational attempts to pipeline multi-scale panomics data for data-driven in silico clinical oncology  ...  Furthermore, the annotation of these single- or multi-scale models with patient data can additionally assist in designing personalized therapeutic interventions as well as aid in clinical decision-making  ...  The platform also acts as a resource to integrate, deposit, track, analyze, as well as disseminate large-scale heterogeneous metabolomics data from a variety of studies.  ... 
doi:10.1101/2021.05.17.444410 fatcat:vbfvmtb5irdapglgkmh5na73je

Patient Empowerment for Cancer Patients through a Novel ICT Infrastructure

Haridimos Kondylakis, Anca Bucur, Chiara Crico, Feng Dong, Norbert Graf, Stefan Hoffman, Lefteris Koumakis, Alice Manenti, Kostas Marias, Ketti Mazzocco, Gabriella Pravettoni, Chiara Renzi (+4 others)
2019 Journal of Biomedical Informatics  
We present in detail the ICT infrastructure developed and our evaluation with the involvement of cancer patients on two sites, a large-scale pilot for adults and a small-scale test for children.  ...  novel decision-support tools are combined into an integrated patient empowerment platform.  ...  The platform was tested on two sites with the involvement of cancer patients, a large-scale pilot for adults and a smallscale test for children.  ... 
doi:10.1016/j.jbi.2019.103342 pmid:31816400 fatcat:zwarguz2a5brjiclzxqivv5zuq

Precision medicine needs pioneering clinical bioinformaticians

Gonzalo Gómez-López, Joaquín Dopazo, Juan C. Cigudosa, Alfonso Valencia, Fátima Al-Shahrour
2017 Briefings in Bioinformatics  
Success in precision medicine depends on accessing high-quality genetic and molecular data from large, well-annotated patient cohorts that couple biological samples to comprehensive clinical data, which  ...  From such a scenario emerges the need for a new professional profile, an expert bioinformatician with training in clinical areas who can make sense of multi-omics data to improve therapeutic interventions  ...  Acknowledgements Authors would like to thank all members from CNIO Bioinformatics Unit for their comments, all of which have helped improve this manuscript.  ... 
doi:10.1093/bib/bbx144 pmid:29077790 fatcat:qvbvzunnavfcnjd7w5dqu3qp2m

Genomics big data hybrid depositories architecture to unlock precision medicine: a conceptual framework

Ummul H. Mohamad, Mohamad T. Ijab, Rabiah A. Kadir
2018 International Journal of Engineering & Technology  
Therefore, based on the extensive literature review on the data driven genomics challenges towards precision medicine, this paper proposes two new contributions to the field; the conceptual framework for  ...  By tailoring each individual medical treatment through precision medicine, it will potentially lead to nearly zero occurrence of the drugs side effects and treatment complications.  ...  Unlike ODMedit, p-medicine, a medical informatics platform, was able to work with variable format of heterogenous patients data [48] .  ... 
doi:10.14419/ijet.v7i4.16893 fatcat:4lgua7ixtbcxhhcwvenadbc2va

Big Data Analytics for Medication Management in Diabetes Mellitus

Lidong Wang, Cheryl Ann Alexander
2016 International Journal of Studies in Nursing  
Providers rely on pharmaceutical companies to provide research data in widespread formats and pharmaceutical companies rely on hospitals for electronic medical record data (EHR) and for pharmacy refill  ...  Medication development plays a prominent role in the fight against chronic illness such as hypertension, diabetes mellitus, asthma, etc.  ...  Integration Challenge in integrating unstructured data; three types of challenges (functional, metadata and instance integration) in transforming and integrating large heterogeneous structured data  ... 
doi:10.20849/ijsn.v1i1.99 fatcat:roof5auh5fdtfaituf4gvhbm34

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

Ruggero De Maria Marchiano, Gabriele Di Sante, Geny Piro, Carmine Carbone, Giampaolo Tortora, Luca Boldrini, Antonella Pietragalla, Gennaro Daniele, Maria Tredicine, Alfredo Cesario, Vincenzo Valentini, Daniela Gallo (+3 others)
2021 Journal of Personalized Medicine  
Multi-modality data integration is necessary for example in precision oncology where an Avatar interface allows several simulations in order to define the best therapeutic scheme for each cancer patient  ...  The spread of "multi-omics" analysis and the use of sensors, together with the ability to acquire clinical, behavioral, and environmental information on a large scale, will allow the digitization of the  ...  the so-called 6-P medicine era (Predictive, Preventive, Personalized, Participatory, Psychosocial, and Public).  ... 
doi:10.3390/jpm11030216 pmid:33803592 fatcat:ljkyarwy7bbwnkrzlnk55vgupy

A vision and strategy for the virtual physiological human: 2012 update

P. Hunter, T. Chapman, P. V. Coveney, B. de Bono, V. Diaz, J. Fenner, A. F. Frangi, P. Harris, R. Hose, P. Kohl, P. Lawford, K. McCormack (+12 others)
2013 Interface Focus  
One contribution of 25 to a Theme Issue 'The virtual physiological human: integrative approaches to computational biomedicine'.  ...  for the project.  ...  principles provide the only method for guiding experimental measurement and integrating and interpreting large amounts of heterogeneous data.  ... 
doi:10.1098/rsfs.2013.0004 pmid:24427536 pmcid:PMC3638492 fatcat:2waldmlms5apzcfmujmchsntzq

Patient Empowerment through Personal Medical Recommendations

Haridimos Kondylakis, Lefteris Koumakis, Eleni Kazantzaki, Maria Chatzimina, Maria Psaraki, Kostas Marias, Manolis Tsiknakis
2015 Studies in Health Technology and Informatics  
This paper presents a platform which empowers patients by allowing searching in a high quality document repository.  ...  While this type of patient empowerment is widely regarded as having a positive influence on the treatment, there exists the problem that the quality of information that can be found on online is very diverse  ...  Acknowledgements This work has been supported by the EU projects p-Medicine, EURECA and MyHealthAvatar and has been partially funded by the European Commission under contracts FP7-270089, FP7-288048 and  ... 
pmid:26262416 fatcat:ityzufjt4zavhkzh5r5wa4fzoy

Making sense of big data in health research: Towards an EU action plan

Charles Auffray, Rudi Balling, Inês Barroso, László Bencze, Mikael Benson, Jay Bergeron, Enrique Bernal-Delgado, Niklas Blomberg, Christoph Bock, Ana Conesa, Susanna Del Signore, Christophe Delogne (+45 others)
2016 Genome Medicine  
The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently.  ...  There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving.  ...  Online environments such as VPH-Share and projects such as p-medicine have appropriate infrastructures for these applications [81] .  ... 
doi:10.1186/s13073-016-0323-y pmid:27338147 pmcid:PMC4919856 fatcat:uvvzkculmnf5lfnyn5u2nvegmm
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