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miRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson's disease

Xiaoting Liu, Jinhu Chen, Tianyuan Guan, Hui Yao, Wenpei Zhang, Zhenlong Guan, Yanqin Wang
2019 BMC Systems Biology  
The aim of this study is to construct a molecular network to find molecules that play important roles in the progression of PD with the goal of using them diagnostically and for early intervention.  ...  Parkinson's disease (PD) is the second most common neurodegenerative disease, and it is a multifactorial disease with no definite diagnostic index.  ...  Since miRNAs are a key mechanism for controlling gene expression, regulatory miRNAs and their target genes can serve as biomarkers for the early diagnosis of PD. miRNAs and their derivatives have great  ... 
doi:10.1186/s12918-019-0680-4 pmid:30665415 pmcid:PMC6341689 fatcat:rfan62nv2ffdxllp63jbxxjj5m

Correction to: miRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson's disease

Xiaoting Liu, Jinhu Chen, Tianyuan Guan, Hui Yao, Wenpei Zhang, Zhenlong Guan, Yanqin Wang
2019 BMC Systems Biology  
AbstractIt was highlighted that the original article [1] contained some typesetting mistakes in the first paragraph of the Background section.  ...  Early identification of PD molecular biomarkers is critical for initiating timely treatment prior to the onset of motor symptoms.  ...  Early identification of PD molecular biomarkers is critical for initiating timely treatment prior to the onset of motor symptoms.  ... 
doi:10.1186/s12918-019-0701-3 pmid:30755197 pmcid:PMC6372997 fatcat:ffctzh3dx5e7pkumr2nug44xqe

Identification of microRNAs for the early diagnosis of Parkinson's disease and multiple system atrophy

Jia-Hui Yan, Ping Hua, Yong Chen, Lan-Ting Li, Cui-Yu Yu, Lei Yan, Hui Zhang, Ying He, Hao Zheng, Hui Chen, Zhao-Jing Zhang, Qi-Hui Yao (+2 others)
2020 Journal of Integrative Neuroscience  
Our results demonstrate that the distinctive characteristics of microRNAs differentiate Parkinson's disease and multiple system atrophy patients from healthy controls and may be used for the early diagnosis  ...  To investigate the expression levels of the 7 serum microRNAs in Parkinson's disease and multiple system atrophy, 23 early Parkinson's disease patients (who did not take any anti- Parkinson's disease drugs  ...  Acknowledgments Conflict of Interest The authors declare no conflict of interest.  ... 
doi:10.31083/j.jin.2020.03.163 pmid:33070521 fatcat:p7q263htrbaappauysf76atlfi

Elevated Plasma microRNA-105-5p Level in Patients With Idiopathic Parkinson's Disease: A Potential Disease Biomarker

Zhaofei Yang, Tianbai Li, Yanhua Cui, Song Li, Cheng Cheng, Bairong Shen, Weidong Le
2019 Frontiers in Neuroscience  
Parkinson's disease (PD) is the second most common neurodegenerative disease, which still lacks a biomarker to aid in diagnosis and to differentiate diagnosis at the early stage of the disease. microRNAs  ...  Several miRNAs have been proposed as potential biomarkers in several diseases.  ...  Molecular markers of early parkinson’s disease based on gene expression in blood. Proc. Natl. Acad. Sci.  ... 
doi:10.3389/fnins.2019.00218 pmid:30936821 pmcid:PMC6431626 fatcat:yeixgl5xizbxjmqted6clwzkju

Circulating miRNAs as Biomarkers for Neurodegenerative Disorders

Margherita Grasso, Paola Piscopo, Annamaria Confaloni, Michela Denti
2014 Molecules  
application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets.  ...  Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible  ...  The advances in the analyses of circulating miRNA summarized here could lead to more efforts toward using miRNAs as biomarkers for neurodegenerative diseases in order to ease an early diagnosis and identify  ... 
doi:10.3390/molecules19056891 pmid:24858274 fatcat:hwiv6b45fbcmbiccqp2u7ui4ea

A compound downregulation of SRRM2 and miR-27a-3p with upregulation of miR-27b-3p in PBMCs of Parkinson's patients is associated with the early stage onset of disease

Soudabeh Fazeli, Majid Motovali-Bashi, Maryam Peymani, Motahare-Sadat Hashemi, Masoud Etemadifar, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi, Hiroyoshi Ariga
2020 PLoS ONE  
Blood-based biomarkers, which are minimally invasive, potentially used for diagnosis of PD, including miRNAs.  ...  The aim of this study was to assess whether SRRM2 and miR-27a/b-3p could act as early diagnostic biomarkers for PD.  ...  MicroRNAs and target genes as biomarkers for the diagnosis of early onset of parkinson disease.  ... 
doi:10.1371/journal.pone.0240855 pmid:33171483 fatcat:ujssaxplenaovbnqgqbc6ghzpy

NEURODEGENERATIVE DISORDERS

1993 Psychiatric Genetics  
application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets.  ...  Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible  ...  The advances in the analyses of circulating miRNA summarized here could lead to more efforts toward using miRNAs as biomarkers for neurodegenerative diseases in order to ease an early diagnosis and identify  ... 
doi:10.1097/00041444-199323000-00019 fatcat:7ft4cwr6bvgovm3khggmxdsdwa

17 Neurodegenerative Disorders [chapter]

Val M. Runge, John N. Morelli
2011 Essentials of Clinical MR  
application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets.  ...  Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible  ...  The advances in the analyses of circulating miRNA summarized here could lead to more efforts toward using miRNAs as biomarkers for neurodegenerative diseases in order to ease an early diagnosis and identify  ... 
doi:10.1055/b-0034-75424 fatcat:tphdisymurgalm6lvtmx3lntqu

Neurodegenerative Disorders

1997 Brain Pathology  
application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets.  ...  Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible  ...  The advances in the analyses of circulating miRNA summarized here could lead to more efforts toward using miRNAs as biomarkers for neurodegenerative diseases in order to ease an early diagnosis and identify  ... 
doi:10.1111/j.1750-3639.1997.tb01043.x fatcat:3zzzfim5kvhbngh2jnjklmerca

Neurodegenerative disorders

2008 Journal of Neurochemistry  
application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets.  ...  Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible  ...  The advances in the analyses of circulating miRNA summarized here could lead to more efforts toward using miRNAs as biomarkers for neurodegenerative diseases in order to ease an early diagnosis and identify  ... 
doi:10.1046/j..2003.0c7-1.x fatcat:k27drtufdnapzc5ykm7ml63emq

miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson's disease

Marcia Cristina T. dos Santos, Miguel Arturo Barreto-Sanz, Bruna Renata S. Correia, Rosie Bell, Catherine Widnall, Luis Tosar Perez, Caroline Berteau, Claudia Schulte, Dieter Scheller, Daniela Berg, Walter Maetzler, Pedro A. F. Galante (+1 others)
2018 OncoTarget  
We performed a gene ontology analysis for the genes targeted by the microRNAs present in each panel and showed the likely association of the models with pathways involved in PD pathogenesis. www.oncotarget.com  ...  Parkinson's Disease is the second most common neurodegenerative disorder, affecting 1-2% of the elderly population.  ...  of target genes [16] .  ... 
doi:10.18632/oncotarget.24736 pmid:29707120 pmcid:PMC5915128 fatcat:oauxcnjznzbupoxzf6dnlvwdjy

A Potential Biomarker MicroRNAs in the Diagnosis of Some Psychiatric and Neurodegenerative Disorders

Fatma AKAT, Hüsamettin VATANSEV, Derya KARAOĞLU
2020 Journal of Contemporary Medicine  
These; diagnostic biomarkers for early diagnosis of the disease, screening biomarkers referring to seeking illness in people with no signs of disease, prognostic biomarkers to predict the course of the  ...  It has been emphasized that serum BDNF and related miRNAs can be used as biomarkers for diagnosis or as therapeutic targets of depression.  ... 
doi:10.16899/jcm.773570 fatcat:buyvst32tja4dpkydxsu5pmxry

Circulating MicroRNAs and Long Non-coding RNAs as Potential Diagnostic Biomarkers for Parkinson's Disease

Yimin Yang, Yanhua Li, Hongmei Yang, Jianxing Guo, Nan Li
2021 Frontiers in Molecular Neuroscience  
In short, the determination of abnormally expressed circulating miRNAs and lncRNAs will be valuable for the future diagnosis and treatment of PD.  ...  In recent years, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are considered to be effective biomarkers for various diseases due to their stability, and resistance to RNAase digestion and extreme  ...  Below, we introduce blood and CSF miRNAs as potential biomarkers for a PD diagnosis.  ... 
doi:10.3389/fnmol.2021.631553 pmid:33762908 pmcid:PMC7982809 fatcat:2sbpr7ckjbbmtiqsoay4bnjc4i

Molecular diagnostics of neurodegenerative disorders

Megha Agrawal, Abhijit Biswas
2015 Frontiers in Molecular Biosciences  
Acknowledgments The authors wish to thank their respective parents for their support and encouragement.  ...  The potential role of MRS as an in-vivo molecular imaging biomarker was investigated for early diagnosis of PD and for monitoring the efficacy of therapeutic interventions (Ciurleo et al., 2014) .  ...  Parkinson's Disease The search for molecular diagnostics biomarkers in PD is critical to identify the disease in early stages which will allow monitoring the effectiveness of neuroprotective therapies  ... 
doi:10.3389/fmolb.2015.00054 pmid:26442283 pmcid:PMC4585189 fatcat:zmpx6hdk7besbloztwisxuslyi

Roles of Non-Coding RNAs as Novel Diagnostic Biomarkers in Parkinson's Disease

Ida Manna, Andrea Quattrone, Selene De Benedittis, Enrico Iaccino, Aldo Quattrone
2021 Journal of Parkinson's Disease  
expressed in PD, highlighting their potential for being considered as biomarkers for diagnosis.  ...  Together, these studies hold promise for the use of peripheral biomarkers for the diagnosis of PD.  ...  Early disease biomark-732 ers are still unknown and new future genetic targets 733 are urgently needed.  ... 
doi:10.3233/jpd-212726 pmid:34334422 pmcid:PMC8609715 fatcat:j2bry7v67bh7jpvnkogdlc7d7i
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