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miR-30a-5p Regulates Viability, Migration, and Invasion of Lung Adenocarcinoma Cells via Targeting ECT2

Sangsang Chen, Xuqing Zhu, Jing Zheng, Tingting Xu, Yinmin Xu, Feng Chen, Tao Huang
2021 Computational and Mathematical Methods in Medicine  
Downregulation of ECT2 could inhibit the viability, migration, and invasion of LUAD cells, which could be reversed by simultaneously suppressing the expression of miR-30a-5p. Conclusion.  ...  Our results suggested that miR-30a-5p repressed the malignant progression of LUAD via downregulating ECT2. miR-30a-5p and ECT2 may be effective targets for LUAD patients.  ...  The authors state no conflicts of interest.  ... 
doi:10.1155/2021/6241469 pmid:34306175 pmcid:PMC8279846 fatcat:luhcxj5kane2thjjlzyx3axfcq

Identification of potential core genes in hepatoblastoma via bioinformatics analysis [article]

Basavaraj Mallikarjunayya Vastrad, Chanabasayya Mallikarjunayya Vastrad, Iranna B Kotturshetti
2020 medRxiv   pre-print
A total of 996 DEGs were identified, consisting of 499 up regulated genes and 497 down regulated genes.  ...  Validation of hub genes showed that TP53, PLK1, AURKA, CDK1, ANLN, ESR1, FGB, ACAT1, GOT1 and ALAS1 may be involved in the carcinogenesis, invasion or recurrence of hepatoblastoma.  ...  regulates cell migration and invasion.  ... 
doi:10.1101/2020.12.22.20248756 fatcat:jnxeahsjqvgffaqgxcx6bn4ska

Identification of Key Genes and Signaling Pathways Associated with the Progression of Glioblastoma multiform [article]

Basavaraj Mallikarjunayya Vastrad, Chanabasayya Mallikarjunayya Vastrad, Iranna B Kotturshetti
2020 medRxiv   pre-print
The results indicated that a total of 947 differential expressed genes (DEGs) (477 up regulated and 470 down regulated) was identified in microarray profiles.  ...  In addition, a target gene - miRNA regulatory network and target gene - TF regulatory network in GBM were constructed using common deregulated miRNAs, TFs and DEGs.  ...  MiR-200c-3p inhibits cell migration and invasion of clear cell renal cell carcinoma via regulating SLC6A1. Cancer Biol Ther. 2018;19(4):282-291. doi:10.1080/15384047.2017.1394551 133.  ... 
doi:10.1101/2020.12.21.20248616 fatcat:k5qiew6kjrcjnf5iuz6cyqnaxe