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Identification of Implications of Angiogenesis and m6A Modification on Immunosuppression and Therapeutic Sensitivity in Low-Grade Glioma by Network Computational Analysis of Subtypes and Signatures

Bo Li, Fang Wang, Nan Wang, Kuiyuan Hou, Jianyang Du
2022 Frontiers in Immunology  
In the hypoxic environment of intracranial tumor immune microenvironment (TIME), m6A modifications in glioma stem cells are predominantly distributed around neovascularization and synergize with complex  ...  Angiogenesis is a complex process in the immunosuppressed low-grade gliomas (LGG) microenvironment and is regulated by multiple factors.  ...  In addition, we thank Associate JD for technical support in R, Python, and Linux.  ... 
doi:10.3389/fimmu.2022.871564 pmid:35572524 pmcid:PMC9094412 fatcat:jmlbq3bx3fg3xd4jvtodv6tyea

Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas

Shengchao Xu, Lu Tang, Gan Dai, Chengke Luo, Zhixiong Liu
2020 Frontiers in Cell and Developmental Biology  
The expression of m6A regulators was associated with prognoses, grade, isocitrate dehydrogenase (IDH) status, and 1p19q status of gliomas.  ...  N6-methyladenosine (m6A) RNA methylation and tumor immune microenvironment played crucial roles in cancer development. However, their association in gliomas remains to be fully elucidated.  ...  AUTHOR CONTRIBUTIONS ZL and CL conceived, designed, and supervised the study. SX and LT drafted the manuscript. SX, LT, and GD collected the data. SX performed all data analysis.  ... 
doi:10.3389/fcell.2020.594112 pmid:33240891 pmcid:PMC7683617 fatcat:u2rqqcu24rgynpdvg62z5kayeq

Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma

Shaojian Lin, Houshi Xu, Anke Zhang, Yunjia Ni, Yuanzhi Xu, Tong Meng, Mingjie Wang, Meiqing Lou
2020 Frontiers in Oncology  
Consensus clustering was applied to the m6A RNA methylation regulators, and two glioma subgroups were identified with a poorer prognosis and a higher grade of WHO classification in cluster 1.  ...  Moreover, we also found PDPN and TIMP1 were highly expressed in high-grade glioma from The Human Protein Atlas database and both of them were correlated with m6A and immune cell marker in glioma tissue  ...  However, the potential roles of m6A modification in immune infiltration remain obscure, especially in glioma.  ... 
doi:10.3389/fonc.2020.541401 pmid:33123464 pmcid:PMC7571468 fatcat:fmrz4erkvjh2fmkvm6uavvlvya

Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of N6-Methyladenosine RNA Modification Regulators in Human Cancers

Rui Li, Yun-Hong Yin, Xiu-Li Ji, Xiao Liu, Jian-Ping Li, Yi-Qing Qu
2021 Frontiers in Molecular Biosciences  
Our study identified the imperative role of m6A regulators in the tumor immune microenvironment, survival, stemness score, and anticancer drug sensitivity of pan-cancer.  ...  Our study provides a comprehensive insight for revealing the significant role of m6A regulators in the tumor immune microenvironment, stemness score, and anticancer drug sensitivity of human cancers.  ...  non-small cell lung cancer, melanoma, and pediatric low-grade glioma (Weerink et al., 2017) .  ... 
doi:10.3389/fmolb.2021.644620 pmid:34150845 pmcid:PMC8211991 fatcat:gjvxa3ndabapngvtizdbnqadfu

Identification of Critical m6A RNA Methylation Regulators with Prognostic Value in Lower-Grade Glioma

Jianglin Zheng, Xuan Wang, Yue Qiu, Minjie Wang, Hao Yu, Zijie Zhou, Zhipeng Wu, Xiaobing Jiang, Nagarajan Raju
2021 BioMed Research International  
So far, there has been little comprehension about the effects of m6A RNA methylation regulators on lower-grade gliomas (LGG).  ...  Increasing evidences have revealed that N6-methyladenosine (m6A) RNA methylation regulators participate in the tumorigenesis and development of multiple tumors.  ...  Conflicts of Interest The authors declare that there is no conflict of interest regarding the publication of this paper.  ... 
doi:10.1155/2021/9959212 pmid:34212046 pmcid:PMC8205593 fatcat:f52ww3xe5vfmbeu6jtps5fahy4

Expression Pattern and Prognostic Value of Key Regulators for m6A RNA Modification in Hepatocellular Carcinoma

Lele Zhang, Yiting Qiao, Jiacheng Huang, Dalong Wan, Lin Zhou, Shengzhang Lin, Shusen Zheng
2020 Frontiers in Medicine  
Herein, we sought to investigate the expression pattern of 13 key regulators for m6A RNA modification and to evaluate their prognostic value in HCC.  ...  In summary, we herein uncovered the vital role of regulators for m6A RNA modification in HCC and developed a risk signature as a promising prognostic marker in HCC patients.  ...  SL and SZ were responsible for the supervision of the work. All authors contributed to the article and approved the submitted version.  ... 
doi:10.3389/fmed.2020.00556 pmid:33072775 pmcid:PMC7534531 fatcat:abnoi64vxfhofcwsv6t74zy6bu

Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma

Jianyang Du, Kuiyuan Hou, Shan Mi, Hang Ji, Shuai Ma, Yixu Ba, Shaoshan Hu, Rui Xie, Lei Chen
2020 Frontiers in Oncology  
N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by the m6A RNA methylation regulators ("writers," "erasers," and "readers"), has been reported to be associated  ...  Finally, we derived a risk-gene signature with three selected m6A RNA methylation regulators, which allowed us to extend the in-depth study and dichotomized the OS of patients with GBM into high- and low-risk  ...  ACKNOWLEDGMENTS The authors gratefully acknowledge contributions from the CGGA network, the TCGA network, and the GTEx network.  ... 
doi:10.3389/fonc.2020.00208 pmid:32211315 pmcid:PMC7075451 fatcat:dldvh7oe35a2tgtfwi65yk5zoa

Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas

Zhen Chen, Zhe Zhang, Wei Ding, Jie-hui Zhang, Zi-long Tan, Yu-ran Mei, Wei He, Xiao-jing Wang
2022 Frontiers in Neurology  
However, the expression patterns and function of the m7G RNA methylation regulator in gliomas are yet unknown.  ...  The goal of this study was to examine the expression patterns of 31 critical regulators linked with m7G RNA methylation and their prognostic significance in gliomas.  ...  Recent studies have reported that m6A RNA methylation regulators are critical in maintaining glioma stem cells and radioresistance and have a potential role in prognostic and therapeutic strategy development  ... 
doi:10.3389/fneur.2022.886246 fatcat:fqkcqm6rsffxvjkmv6fxrvlcs4

Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma

Xian Chang, Yang-Fan Lv, Jing He, Ya Cao, Chang-Qing Li, Qiao-Nan Guo
2021 Journal of Hepatocellular Carcinoma  
N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of mammalian RNA, and it is associated with tumorigenesis and cancer progression.  ...  Its regulation is mediated via m6A-related regulators, including "erasers," "readers," and "writers".  ...  Author Contributions All authors made a significant contribution to the work, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these  ... 
doi:10.2147/jhc.s296438 pmid:33738268 pmcid:PMC7966299 fatcat:ldkupayk7vf2nlymcakpx53kiu

Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma

Yi Jin, Zhanwang Wang, Dong He, Yuxing Zhu, Xueying Hu, Lian Gong, Mengqing Xiao, Xingyu Chen, Yaxin Cheng, Ke Cao
2021 Frontiers in Immunology  
N6-methyladenosine methylation (m6A) is the most common modification to affect cancer development, but to date, the potential role of m6A regulators in ACC prognosis is not well understood.  ...  We identified three m6A modification patterns with different clinical outcomes and discovered a significant relationship between diverse m6A clusters and the tumor immune microenvironment (immune cell  ...  Additionally, Zewei Tu reportedly built a ceRNA network and established a 9 m6A-related lncRNA prognostic model in lower-grade glioma patients (20) .  ... 
doi:10.3389/fimmu.2021.637933 pmid:33746977 pmcid:PMC7966528 fatcat:vo2lj7co6reyjca7axilyqgeyy

Comprehensive analysis of the PD-L1 and immune infiltrates of m6A RNA methylation regulators in head and neck squamous cell carcinoma

Lilan Yi, Guowu Wu, Longhua Guo, Xiaofang Zou, Ping Huang
2020 Molecular Therapy: Nucleic Acids  
Collectively, our study elucidated the important role of m6A methylation in TIME of HNSCC.  ...  The proposed m6A regulator-based signatures might serve as crucial mediators of TIME in HNSCC, representing promising therapeutic targets in improving immunotherapeutic efficacy.  ...  N6-methyladenosine (m 6 A), the methylation modification at the sixth N atom of adenine, is the most common post-transcriptional modification on mRNA, mediating >60% RNA methylation. 5, 6 Abnormal m  ... 
doi:10.1016/j.omtn.2020.06.001 pmid:32622331 pmcid:PMC7332506 fatcat:u52vfinb4zeoje7g7lesmhsc54

Identification of an m6A RNA Methylation Regulator Risk Score Model for Prediction of Clinical Prognosis in Astrocytoma

Fangzhou Guo, Teng Deng, Liu Shi, Pinghua Wu, Jun Yan, Guoyuan Ling, Hainan Chen, Qianrong Huang, Junbo Mu, Ligen Mo, Osamah Ibrahim Khalaf
2022 Computational and Mathematical Methods in Medicine  
A total of 579 AS patients' (of the Chinese Glioma Genome Atlas,CGGA) data and the expression of 12 published m6A-related genes were included in this study.  ...  The vital involvement of the N6-methyladenosine (m6A) RNA modification in the growth of multiple human tumors is known.  ...  Results The Pattern of Regulators in AS. The expression of each m6A RNA methylation regulator scrutinized of the malignant vs. control samples is depicted as a heat map (Figure 1(a) ).  ... 
doi:10.1155/2022/7168929 pmid:35047056 pmcid:PMC8763512 fatcat:64x2iry7onekpncqnxumljxgxq

RNA m6A methylation regulators in ovarian cancer

Jialu Guo, Jianfeng Zheng, Huizhi Zhang, Jinyi Tong
2021 Cancer Cell International  
In this review, the latest studies on m6A and its regulators in OC have been summarized, and we focus on the key role of m6A modification in the development and progression of OC.  ...  Additionally, we also discuss the potential use of m6A modification and its regulators in the diagnosis and treatment of OC.  ...  Fig. 1 Dynamic m6A RNA modification and mediated functions. M6A mRNA methylation is regulated by methyltransferases ("writers"), demethylases ("erasers") and m6A-binding proteins ("readers").  ... 
doi:10.1186/s12935-021-02318-8 pmid:34794452 pmcid:PMC8600856 fatcat:bcxkobx7azauxkwb65zhfhnr4y

Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma

Enakshi Sivasudhan, Neil Blake, Zhi-Liang Lu, Jia Meng, Rong Rong
2021 Frontiers in Cell and Developmental Biology  
In this review, we reveal the up-to-date knowledge on the mechanistic and functional link between m6A RNA methylation and pathogenesis of HCC.  ...  In particular, the underlying cellular mechanisms of different hallmarks of hepatocarcinogenesis that are governed by the complex dynamics of m6A RNA methylation demand further investigation.  ...  TABLE 1 | 1 Role of m6A methylome in hepatocarcinogenesis. m6A regulator type m6A regulator Expression pattern Function in hepatocellular carcinoma* References Writer METTL3 Upregulated METTL3  ... 
doi:10.3389/fcell.2021.642443 pmid:33869193 pmcid:PMC8047153 fatcat:b4wov6iyffeqvji6muja5w2pnu

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

Peng-Ju Gong, You-Cheng Shao, Yan Yang, Wen-Jing Song, Xin He, Yi-Fan Zeng, Si-Rui Huang, Lei Wei, Jing-Wei Zhang
2020 Frontiers in Oncology  
METTL14 and ZC3H13 were the down-regulated m6A methylation transferases in breast cancer.  ...  of m6A methylation transferases (METTL3, METTL14, WTAP, RBM15, RBM15B and ZC3H13) and investigate the prognostic value of METTL14 and ZC3H13 in breast cancer.  ...  WTAP expression was up-regulated in hepatocellular carcinoma; WTAP-mediated m6A modification led to epigenetic silencing of the tumor suppressor gene ETS1, and promoted the progression of hepatocellular  ... 
doi:10.3389/fonc.2020.578963 pmid:33363011 pmcid:PMC7757663 fatcat:dvfyuq5kknd25djxc6l5lkrupu
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