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Gastrointestinal Organoids: A Next Generation Tool for Modeling Human Development

Akaljot Singh, Holly M Poling, Jason R Spence, James M. Wells, Michael Anthony Helmrath
2020 American Journal of Physiology - Gastrointestinal and Liver Physiology  
Gastrointestinal organoids are an exciting new tool for modeling human development, physiology, and disease in human tissue. Derived from pluripotent stem cells (PSCs), gastrointestinal organoids consist of epithelial and mesenchymal cells organized in an intricate, three-dimensional structure that recapitulates the physiology and microscopic anatomy of the human GI tract. In vitro derivation of gastrointestinal organoids from Definitive Endoderm has permitted an exploration of the complex
more » ... of the complex signaling pathways required for the initial maturation of each individual gastrointestinal organ. Further maturation beyond an early fetal state currently requires transplantation into an immunocompromised host. Transplantation induced maturation provides an opportunity to functionally interrogate the key mechanisms underlying development of the human GI tract. Gastrointestinal organoids can also be used to model human diseases, and ultimately may serve as the basis for developing novel, personalized therapies for human intestinal diseases.
doi:10.1152/ajpgi.00199.2020 pmid:32658619 fatcat:bgr6isrpsrff5gguabzbareks4