A COMPARATIVE STUDY OF ATENOLOL AND PROPRANOLOL ON CHEMODYNAMICS AND LIPID PROFILE IN ALCOHOLIC HYPERTENSIVE PATIENTS
Journal of Evidence Based Medicine and Healthcare
INTRODUCTION: In developing countries particularly in India, the constitutions of the diseases, showing a fatal cause has considerably changed during the recent period. Lifestyle related diseases such as Cancer, Cardio-Vascular, Metabolic and Allergic diseases have accounted for the majority of the diseases showing a fatal course. The disease structure of Indian People has undergone radical changes in last few years. Tuberculosis which used to be the highest cause of death has decreased
... s decreased greatly. On the other hand incidents of Malignant Neoplasm and Heart diseases have substantially increased. Today these diseases which are closely related to life style of individuals account for 60% of all causes of death. Considering the fact that the natural course of these diseases from onset to death is extensive, it is quite meaningful to reveal the risk factors for the occurrence of Cardio-Vascular diseases. The mortality rate associated with Cardio-Vascular Heart diseases in Indian People is on the increase from the global aspect. The main risk factors for ischaemic heart disease are hypertension Hyper-cholesterolemia and cigarette smoking. The other factors being obesity alcohol drinking, exercise, stress and Glucose intolerance. As hypertension is now adequately controlled, ischaemic Heart disease can be prevented to a certain degree. However, the recent National Study of Cardio-Vascular diseases shows higher mean Cholesterol values, therefore, the tend in occurrence of hyper cholesterolemia and ischaemic Heart disease should be watched carefully. According to the previous studies (Morimotta. K. et al 2000) 1 smokers showed a decrease in HDL by approximately 6% and an increase in LDL as compared to non-smokers. This shows that smoking had adverse influence on lipid balance in blood. On the other hand continuous exercise accompanying weight loss, increased HDL by approximately 5% and decreased LDL by approximately 10%. This shows that exercise is the most effective lifestyle for the lipid balance in blood (Craig. W.Y. et al 1989). Light to moderate alcohol drinking has shown to increase HDL but excess drinking increases TG and thus results in the increase of the risk of cardiovascular disease (Thun M. J. et al 1997). 2 The other main risk factor of cardiovascular diseases is hypertension. At present the number of hypertension patients is on the increase and approximately 90% of them have essential HT without distinct underlying disease. The relation between the onset of hypertension to alcohol drinking dietary life, obesity and lack of exercise has been advocated in most literature (Hagberg, J.M. et al 1990) . 3 A report on the influence of alcohol drinking on hypertension has shown that diastolic % systolic B.P.