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Structure of caa3 cytochrome c oxidase – a nature-made enzyme-substrate complex

Mohamed Radzi Noor, Tewfik Soulimane
2013 Biological chemistry  
Aerobic respiration, the energetically most favorable metabolic reaction, depends on the action of terminal oxidases that include cytochrome c oxidases. The latter forms a part of the heme-copper oxidase superfamily and consists of three different families (A, B, and C types). The crystal structures of all families have now been determined, allowing a detailed structural comparison from evolutionary and functional perspectives. The A2-type oxidase, exemplified by the Thermus thermophilus caa 3
more » ... thermophilus caa 3 oxidase, contains the substrate cytochrome c covalently bound to the enzyme complex. In this article, we highlight the various features of caa 3 enzyme and provide a discussion of their importance, including the variations in the proton and electron transfer pathways.
doi:10.1515/hsz-2012-0343 pmid:23399637 fatcat:4szigtmylvcfvlwaw4gonpjrwe