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Objectives The Frailty index (FI) calculates frailty as the sum of health deficits divided by the total number of variables and reflects biopsychosocial and cultural determinants of well-being. A Colonia is a predominantly Hispanic, economically distressed, unincorporated neighborhood and varies in resources according to geographic location and contributors to social determinants of health. We report baseline Frailty Index data from two Colonias in South Texas. This information serves as adoi:10.21203/rs.3.rs-22252/v1 fatcat:7ngtnjqgmzakpkf5jn4renfsqa