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Multi-modal measurements of single cell profiles are a powerful tool for characterizing cell states and regulatory mechanisms. While current methods allow profiling of RNA along with either chromatin or protein levels, connecting chromatin state to protein levels remains a barrier. Here, we developed PHAGE-ATAC, a method that uses engineered camelid single-domain antibody ('nanobody')-displaying phages for simultaneous single-cell measurement of surface proteins, chromatin accessibilitydoi:10.1101/2020.10.01.322420 fatcat:wt3x2ka52rfpfo7azp2t65hjw4