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Arylamine N-acetyltransferase 2 genotypes in a Mexican population

L. Taja-Chayeb, J.A. Agúndez, C. Miguez-Muñoz, A. Chavez-Blanco, A. Dueñas-Gonzalez
2012 Genetics and Molecular Research  
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican population. Among 250 samples amplified and sequenced for the NAT2 gene, we found seven different SNPs; the most frequent allele was 803 A>G (35.8%), followed by 282 C>T, 341
more » ... ed by 282 C>T, 341 T>C, and 481 C>T. There were no differences in the distribution of SNPs between healthy subjects and cancer patients. These eight polymorphisms defined 26 diplotypes; 11.6% were wild type (NAT2*4/NAT2*4), while the most common diplotype was NAT2*4/NAT2*5B, present in 17.2%. We did not identify other common polymorphisms. The results were compared with the NAT2 SNPs reported from other populations. All but the ©FUNPEC-RP Genetics and Molecular Research 11 (2): 1082-1092 (2012) NAT2 genotypes in Mexicans Turkish population was significantly different from ours. We conclude that the mixed-race Mexican population requires special attention because NAT2 genotype frequencies differ from those in other regions of the world.
doi:10.4238/2012.april.27.7 pmid:22614277 fatcat:2pohsellmffprihpbn5xxs4vfa