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A Sweet Galactose Transfer – Metabolic Oligosaccharide Engineering as a Tool to Study Glycans in Plasmodium Infection [post]

Annabel Kitowski, Gonçalo Bernardes
2019 unpublished
The use of artificial galactose derivatives and labelling through iEDDA reaction in the liver stage of <i>Plasmodium </i>infection showed increased uptake in infected hepatic cells, through participation of GLUT1 transporters. Furthermore, unprotected derivatives are transferred from the mosquito host to the <i>Plasmodium</i> <i>berghei</i> parasite. This strategy has the potential to provide new insights into <i>Plasmodium</i> glycobiology.
doi:10.26434/chemrxiv.10119302.v1 fatcat:lkrermlwibfdvjsghkoxfdj5la