AN OBSERVATIONAL COMPARATIVE STUDY OF WEIGHT GAIN AND SIALORRHEA IN PATIENTS TAKING TYPICAL AND ATYPICAL ANTIPSYCHOTICS
International Journal of Biology Pharmacy and Allied Sciences
The prevalence of clinically relevant weight gain and obesity has been reported to be four times higher in patients receiving typical or atypical antipsychotic drugs than in general population. Apart from weight gain atypical antipsychotics also cause sialorrhea which can be distressing to psychiatric patients leading to non-adherence to treatment. The present study included 277 patients attending a private psychiatric clinic and counseling centre. Patients were divided based on the use of
... on the use of atypical antipsychotics and combination of both typical and atypical antipsychotics. Details about drug characteristics like number of antipsychotics prescribed, use of anticholinergics, previous history and present occurrence of sialorrhea and weight gain were recorded from patient case sheets and using Simpson Angus Scale.209 (75.5 %) patients were prescribed with atypical antipsychotics and 68 (24.5 %) patients were prescribed with combination of atypical and typical antipsychotics. Of 209 patients on atypical antipsychotics, 62 patients were on atypical mono therapy among which risperidone was most prescribed 15 (24 %) and least prescribed was clozapine 5 (8 %) and levosulpride 1 (2 %). The overall occurrence of sialorrhea is observed more in patients taking combination therapy. The overall occurrence of weight gain with atypical group and combination group is found to be (64 %) and (55 %) respectively. Patient treated with combination therapy had significant social habits compared to atypical therapy. Clozapine was the least prescribed drug. The overall occurrence of sialorrhea is observed more in patients taking combination therapy compared to patients on atypical therapy.