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Gaba-Ergic Dysfunction in Tourette Syndrome

J Gordon Millichap
2012 Pediatric Neurology Briefs  
Cognitive effects of interictal epileptiform EEG discharges. Simultaneous video-EEG recordings and cognitive testing in 188 children with epilepsy found that the association between frequent epileptiform activity and cognitive function, although less pronounced, is comparable to impairment of global cognitive function, central processing speed, and memory function that accompanies short nonconvulsive seizures. (Nicolai J et al. Epilepsia 2012 June;53(6);1051-1059). Transient cognitive
more » ... cognitive impairment (TCI) is demonstrated in about 50% of patients who show epileptiform activity during testing Whether TCI influences school performance is unclear and is not generally an indication for AED therapy. The EEG activation or suppression effect of cognitive tasks is a phenomenon to be recognized in the evaluation of TCI effects on learning. (Binnie CD. Lancet Neurol 2003;2:725-730).
doi:10.15844/pedneurbriefs-26-7-7 fatcat:wi2tzq4u3jbhdnx5nuczratpbm