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Jeffrey J. Nienaber and Hideo Tachibana contributed equally to this work. Conflict of interest: The authors have declared that no conflict of interest exists. Nonstandard abbreviations used: β-adrenergic receptor (βAR); G protein-coupled receptors (GPCRs); phosphatidylinositol (PtdIns); phosphoinositide kinase domain (PIK); phosphatidylinositol-3,4,5-tri-phosphate (PtdIns-3,4,5-P3); inactive mutant of PI3Kγ (PI3Kγinact); PI3Kγ knockout (PI3Kγ-KO); hemagglutinin (HA); transverse aorticdoi:10.1172/jci200318213 fatcat:7xcnubr5w5hmjdg2pxhzfhqqbi