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Quality of Life and characterization of patients with atopic dermatitis in Portugal - QUADEP study

D Carvalho, P Aguiar, P Mendes-Bastos, A Palma-Carlos, J Freitas, P Ferrinho
2019 Journal of investigational allergology & clinical immunology  
To investigate the quality of life (QOL) of and to characterize patients with atopic dermatitis (AD) in Portugal. This was a cross-sectional study of patients with AD and other eczemas. Skindex-29, Skindex-teen, and the Childhood Atopic Dermatitis Impact Scale (CADIS) were the instruments used to assess QOL in adults, teenagers, and children, respectively. The SF-12 was also used, and disease severity was evaluated using the Patient-Oriented SCORAD (PO-SCORAD) instrument. Associations with QOL
more » ... ociations with QOL were assessed based on the odds ratio (OR). P values <.05 and 95%CIs were considered statistically significant. The study population comprised 162 participants aged 0.5-74 years. We found that 37.3% of AD patients consider their disease disabling and that more than half of the patients feel stigmatized by society. The mean Skindex score for AD was 39.68, and the impact on QOL was severe in 44%. "Symptoms" was the most affected category in adults. AD was moderate to severe in 87% of the sample. One of the factors that most influenced poorer QOL in AD was age: with increasing age, the Skindex is likely to increase (OR, 1.03; 95%CI, 1.00-1.06). "Considering the disease a disability" was also associated (OR, 6.72; 95%CI, 2.56-17.63). QOL worsens with increasingly affected body area (OR, 1.07; 95%CI, 1.03-1.11) and the presence of edema (OR, 2.0; 95%CI, 1.23-3.40). This is the first study to provide data on QOL in patients with AD in Portugal. Our data show an expected negative impact. More awareness-raising activities are needed to increase knowledge, decrease stigmatization, and, consequently, address the factors involved in the QOL of patients with AD.
doi:10.18176/jiaci.0443 pmid:31530518 fatcat:ldlxwbi6azgbvd2t3ibhefqpqi