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Hereditary hemochromatosis (HH) is caused by a potentially lethal recessive gene (HFE, C282Y allele) that increases iron absorption and reaches polymorphic levels in Northern European populations. Because persons carrying the allele absorb iron more readily than non-carriers, it has often been suggested HFE is an adaptation to anemia. We hypothesize Pre--print version. Visit http://digitalcommons.wayne.edu/humbiol after 1 October 2015 to acquire the final version. 2 positive selection for HFEdoi:10.13110/humanbiology.87.1.0039 fatcat:znk3qd5eirht3o6f6i6hn5lc34