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Нормализация депо-управляемого входа Ca2+ в модели болезни Альцгеймера

Дарья Гончарова, нанотехнологий и телекоммуникаций Санкт-Петербургский политехнический университет Петра Великого. Институт физики, Алексей Скворцов
2019
Leflunomide, teriflunomide and roflumilast were recently described as possible store-operated calcium channel inhibitors. Store-operated calcium entry and calcium homestasis are disrupted in SH-SY5Y cells with mutant PS1-M146V, associated with Alzheimer's disease. Hyperactivity of STIM2 calcium sensors leads to basal calcium entry, calcium store overload and, subsequently, reduce in store-operated calcium entry. 24-hour incubation with leflunomide and roflumilast normalized store-operated
more » ... tore-operated calcium entry in SH-SY5Y cells, bearing mutant PS1-M146V, comparing to wild-type PS1.
doi:10.18720/spbpu/3/2019/vr/vr19-4289 fatcat:oii7clrjmnbflezmt7z6e3aswu