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Oral Medroxyprogesterone Acetate and Combination Oral Contraceptives for Acute Uterine Bleeding

Malcolm G. Munro, Nakia Mainor, Romie Basu, Mikael Brisinger, Lorena Barreda
2006 Obstetrics and Gynecology  
OBJECTIVE: To compare the efficacy of multidose medroxyprogesterone acetate and a multidose monophasic combined oral contraceptive (OC) for hemodynamically stable women with nongestational, acute uterine bleeding. METHODS: Hemodynamically stable patients with acute uterine bleeding sufficient to justify immediate medical or surgical intervention were enrolled in an open-label, randomized trial comparing oral medroxyprogesterone acetate 20 mg and a monophasic combination OC containing 1 mg
more » ... ntaining 1 mg norethindrone and 35 g of ethinyl estradiol, each administered three times per day. Doses were reduced after 1 week to 20 mg per day and one tablet per day for the next 3 weeks for the medroxyprogesterone acetate and OC groups, respectively. Following baseline assessment, patients completed daily treatment and symptom logs collected at 14 and 28 days after initiation of therapy. RESULTS: Forty patients were randomly assigned, 20 in each group; 33 were evaluated at the 14-day visit. Emergency surgical procedures were avoided in 100% of those women taking medroxyprogesterone acetate and 95% of the OC group. Cessation of bleeding had occurred in 88% of the OC group and 76% of those receiving medroxyprogesterone acetate, with a median time to bleeding cessation of 3 days for both groups. Compliance with therapy was higher in the medroxyprogesterone acetate group than the OC group, but there was no overall difference in the incidence of treatment-related nausea and bloating. CONCLUSION: This randomized trial is limited by sample size but suggests that both regimens may be effective and reasonably well tolerated. CLINICAL TRIAL REGISTRATION: Current Clinical Trials (, Identifier: NCT00350480 (Obstet Gynecol 2006;108:924-9) LEVEL OF EVIDENCE: II-1 A cute uterine bleeding, unrelated to pregnancy,
doi:10.1097/01.aog.0000238343.62063.22 pmid:17012455 fatcat:ez5to3shn5difhwhpugd7xr2bi