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Accurate assessment of the functional consequences of human immunodeficiency virus (HIV) infection and drugs of abuse are critical as large populations are afflicted with both. Both are interdependent epidemics with important socioeconomic consequences. Experimental studies in animal models and in vitro clearly indicate that HIV and drugs of abuse cause increased neurodegeneration, glial cell activation and enhanced HIV replication. Nevertheless, most epidemiological studies and neurocognitivedoi:10.3844/ajidsp.2006.90.97 fatcat:25bvlq3ggrhehnc5vrhagssrpa