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Absolute Structures of Stemona-Lactam S and Tuberostemospiroline, Alkaloids from Stemona tuberosa

Haruhiko Fukaya, Yukio Hitotsuyanagi, Yutaka Aoyagi, Zhu Shu, Katsuko Komatsu, Koichi Takeya
2013 Chemical and pharmaceutical bulletin  
A new alkaloid, stemona-lactam S, and a known alkaloid, tuberostemospiroline, were isolated from the roots of Stemona tuberosa LOUR. (Stemonaceae). Their structures and absolute stereochemistry were established by X-ray crystallography and vibrational circular dichroism. The roots of Stemona japonica (BLUME) MIQ., S. tuberosa LOUR., and S. sessilifolia (MIQ.) MIQ. are used as an antitussive and an insecticide in traditional medicine in China and Japan, and the alkaloidal components are
more » ... onents are responsible for such biological activities. [1] [2] [3] In the course of our work 4,5) on the alkaloids from S. tuberosa, a new alkaloid, stemona-lactam S (1), and a known alkaloid, tuberostemospiroline (2), 6) were isolated from this plant source and their absolute structures were determined by X-ray crystallography and vibrational circular dichroism (VCD) (Fig. 1) .
doi:10.1248/cpb.c13-00454 pmid:24088701 fatcat:jiinkli675bwphoq5a5ofcqrie