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Basal cell carcinomas, the most common human tumors, generally appear sporadically and in small numbers. Rarely, they may appear in great numbers and at an earlier age as a manifestation of the basal cell nevus syndrome, an autosomal dominant inherited disorder. Drawing on the retinoblastoma paradigm, we have begun a search for tumor suppressor genes important in the development of basal cell carcinomas by comparing DNA of tumors and normal cells. Loss of heterozygosity, a frequent marker ofpmid:1540957 fatcat:f2rkhqkhnvbajbcv743cnty6qa