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Ramelteon for Insomnia in Two Youths with Autistic Disorder

Kimberly A. Stigler, David J. Posey, Christopher J. McDougle
2006 Journal of child and adolescent psychopharmacology  
Objective: The aim of this study was to report preliminary data on the effectiveness and tolerability of ramelteon for the treatment of insomnia in youth with autistic disorder (autism). Method: Two youths, ages 7 and 18 years, with autism and significant insomnia characterized by problems with sleep onset and maintenance received an open-label trial of ramelteon (4-8 mg) over a duration of 16-18 weeks. Results: Target symptoms of delayed sleep onset and/or frequent nocturnal awakening improved
more » ... awakening improved significantly, as determined by Clinical Global Impressions-Improvement (CGI-I) scale ratings of either "much improved" or "very much improved." Ramelteon was well tolerated. No daytime sedation was reported. Conclusions: This case report illustrates the potential effectiveness and tolerability of ramelteon for sleep disturbances in 2 patients with autism. Further research is needed to verify its safety, tolerability, and efficacy in children and adolescents with autism.
doi:10.1089/cap.2006.16.631 pmid:17069551 fatcat:xv7lyi6rcfdhplu7wern5hxfoq