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Objective: The aim of this study was to report preliminary data on the effectiveness and tolerability of ramelteon for the treatment of insomnia in youth with autistic disorder (autism). Method: Two youths, ages 7 and 18 years, with autism and significant insomnia characterized by problems with sleep onset and maintenance received an open-label trial of ramelteon (4-8 mg) over a duration of 16-18 weeks. Results: Target symptoms of delayed sleep onset and/or frequent nocturnal awakening improveddoi:10.1089/cap.2006.16.631 pmid:17069551 fatcat:xv7lyi6rcfdhplu7wern5hxfoq