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Development of an in-house HPLC method for the analysis of ecstasy-laced beverages

Kar-Weng Chan, Suraya Hani Ramli
2018 Egyptian Journal of Forensic Sciences  
Pills of ecstasy continue to be the major drug of abuse among nightclub patrons. This stimulant type of substance can be taken orally in many ways, one of which is by drink spiking where the tablet or its powder is deliberately added to some beverage before consumption. Method: A high performance liquid chromatographic (HPLC) method was developed to quantify three analytes (methamphetamine, 3,4-methylenedioxymethamphetamine and ketamine) extracted from beverages associated with drink spiking.
more » ... th drink spiking. Ribena drink, Lipton tea drink and Pepsi soft drink were employed as the target sample matrices for validation studies. Results: The HPLC method was found precise (RSD < 3.2%) and accurate (mean recovery between 97 and 107%) regardless of the matrix type used. The linearity curve for each analyte presented a good regression line with a coefficient of determination, R 2 > 0.994. The method was sensitive to detect at least 0.004 mg/mL spiked drugs and precise to quantify the lowest limit of analytes at 0.02 mg/mL. Conclusion: Analysis of beverages which were contrivedly spiked with genuine ecstasy substances substantiated that the method is fit for the intended purpose.
doi:10.1186/s41935-018-0048-8 fatcat:4tlj4ilckbeaxm4o3pjft4zsju