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The methodology for computer modeling of complex eco-biological models is presented in this paper. It is based on system approach of J. Forrester. Developed methodology is universal for complex ecological and biological systems. Modeling algorithm considers specialties of eco-biological systems and shows adequate and accurate results in practice.doi:10.21122/2309-4923-2015-4-40-44 doaj:6aa868f7a080419fa1fd55e95c51a3c7 fatcat:eptlosee4rccdj75esjtb2zcsa