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The synthesis of thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) were studied in groups of 9 rabbits fed a normal diet or a diet containing 0.3 % of cholesterol. After 16 weeks, a platelet rich suspension containing 300.000 platelets/mm3 was prepared. Portions were incubated at 37°C with arachidonic acid (AA). Biosynthesis of PGE2, TXA2 and TXB2 was evaluated by the bioassay cascade system (rabbit coeliac and mesenteric artery and rat fundus strip) and by radioimmunoassay (RIA) :Nodoi:10.1055/s-0038-1644812 fatcat:w2eef2vsqvg7nkm7vj4zsj4nge