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Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites

C. Bacchi, N. Yarlett
2002 Mini-Reviews in Medical Chemistry  
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono-and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes
more » ... f synthetic enzymes and related pathways.
doi:10.2174/1389557023405549 pmid:12370040 fatcat:tfwywyfptraxvmeczvecghxnxe