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Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C. Eder, Robyn L. Ward, Nicholas J. Hawkins, Richard W. Tothill, Long Chen, Neil J. Mortensen (+3 others)
2014 Cell Reports  
Graphical Abstract Highlights Rad21 is identified as a critical mediator of Apc WT LOH LOH and CIN are formally documented in vitro in primary intestinal cells Rad21 regulates key CRC-associated genes Rad21 is identified as a key driver of L1 retrotransposon expression
doi:10.1016/j.celrep.2014.10.059 pmid:25464844 fatcat:3qqh7yd3fndjdpdk36iluy3vhm