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Physiology and Pathology of Immunology
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by synovial inlammation leading to bone erosion and to systemic manifestations in patients with long RA duration. Although the aetiology is unknown, several observations make currently clear that CD4 T cells play a key role in the pathogenesis: (1) RA associates with certain polymorphisms of HLA class II molecules, and (2) the repertoire and aging of CD4 T cells as well as the intracellular signalling mediating CD4 T celldoi:10.5772/intechopen.70239 fatcat:bnstwb7umfbqfpcz6pvl447hki