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and the Swiss HIV Cohort Study Ã Objective: To assess the impact of primary HIV infection (PHI) on the spread of HIV and the temporal trends in transmission of HIV drug resistance between 1996 and 1999 in Switzerland. Methods: Sequencing of the genes for reverse transcriptase (RT) and protease was performed for 197 individuals with documented PHI. Phylogenetic analyses were confronted with epidemiological data. Results: Signi®cant clustering was demonstrated for 29% of the RT sequences. Alldoi:10.1097/00002030-200111230-00010 pmid:11698702 fatcat:3combtov3veolhowdulbtymsbu