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Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

María Arnoriaga-Rodríguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodríguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnés, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos (+17 others)
2021 Gut  
BackgroundInhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits.MethodsWe studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent
more » ... independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics.ResultsAn interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor's bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient's mice.ConclusionThese results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.
doi:10.1136/gutjnl-2020-323371 pmid:33514598 fatcat:kiilrjdkajg3bgswlf47qgrmva