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Further study of the inhibition of premature labor by indomethacin. Part I [article]

Henryk Zuckerman, Eliezer Shalev, Gabriel Gilad, Eliahu Katzuni, Humboldt-Universität Zu Berlin, Humboldt-Universität Zu Berlin
Premature delivery is the single most important obstetrical complication associated with perinatal mortality and morbidity. An additional one or two weeks of intrauterine existence may decrease neonatal morbidity and mortality. The physiologic aspects of the onset of labor remain an enigma to modern medicine. The exact cause and mechanism of the inhibition of human parturition are unknown and many theories have been advanced to explain the onset of labor: oxytocin, alpha catecholamins,
more » ... cholamins, progesterone drop, estrogen-progesteron ratio elevation, fetal corticosteroids, prostaglandins, changes in uterine blood flow and uterine distension. These factors may also be responsible for premature labor. The problem of how to inhibit labor is not a new one. Traditionally patients have been treated by bed rest, sedation and avoidance of vaginal examinations. Many drugs have also been used including progestogens [9], ethyl alcohol [7], beta adrenergic drugs [16], magnesium sulphate [26] and diazoxide [15]. The marked cardiovascular side effects of the beta adrenergic receptor stimulants may limit their use in the treatment of preterm labor [3]. A role for prostaglandins in spontaneous labor is suggested by their presence in the amniotic fluid [10] in the blood of humans at the onset of labor [32] and by the observation that exogenously administed prostaglandins can induce labor [11, 12] or abortion [13, 21]. There is also good evi- Curriculum vitae HENRYK ZUCKERMAN
doi:10.18452/9967 fatcat:a7jaoe7bdvbmpckcn6zu6g6xm4