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Depressive symptoms have been associated with an increase risk of cognitive decline. Our aim was to evaluate the influence of depressive symptoms on cognition over time in independent older people, accounting for the severity of white matter changes (WMC). The LADIS prospective multi-national European study evaluated the impact of WMC on the transition of independent older subjects into disability. Subjects were evaluated annually over a 3 year period with a comprehensive clinical protocol anddoi:10.1136/jnnp-2012-304191 pmid:23715914 fatcat:yg2jaoit6jei7esdtresyqhlui