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Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children-Short Review

Elena Berghea, Mihaela Balgradean, Ionela-Loredana Popa
2017 Journal of Clinical Medicine STATE OF THE ART 55 Maedica A Journal of Clinical Medicine   unpublished
The idiopathic nephrotic syndrome is a common chronic kidney diseases in children defined by the association of massive proteinuria and hypoalbuminemia in a relapsing/remission course, with histological aspect of minimal changes (also called minimal change disease) in the majority of the cases, but its pathogenesis remains not very well known. Clinical and immunological studies have consistently shown a relationship between atopic diathesis, immunoglobulin E and cytokines involved in
more » ... olved in immunoglobulin E synthesis and idiopathic nephrotic syndrome. Additional research is necessary to clarify this relationship and to explore the contribution of allergic disease to the development of nephrotic syndrome and to identify potential new strategies of diagnosis and treatment.