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HLA-Cw6 is strongly associated with psoriasis and has been suggested to be the PSORS1 gene that confers susceptibility to early-onset psoriasis. In this study of the clinical features of HLA-Cw*0602-positive and -negative psoriasis patients in a Han Chinese population, we typed HLA-C in a cohort of 679 patients and compared the two groups. Cw*0602-positive patients (n=345) had an earlier disease onset (p <1×10 -5 ), more severe disease (p <1×10 -3 ), higher frequency of guttate psoriasis (pdoi:10.2340/00015555-0253 pmid:17598037 fatcat:pcdlh3lrlrhulgo2pr4v4hm5pu