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AWESOME: a database of SNPs that affect protein post-translational modifications

Yang Yang, Xiating Peng, Pingting Ying, Jianbo Tian, Jiaoyuan Li, Juntao Ke, Ying Zhu, Yajie Gong, Danyi Zou, Nan Yang, Xiaoyang Wang, Shufang Mei (+4 others)
2018 Nucleic Acids Research  
Protein post-translational modifications (PTMs), including phosphorylation, ubiquitination, methylation, acetylation, glycosylation et al, are very important biological processes. PTM changes in some critical genes, which may be induced by base-pair substitution, are shown to affect the risk of diseases. Recently, large-scale exome-wide association studies found that missense single nucleotide polymorphisms (SNPs) play an important role in the susceptibility for complex diseases or traits. One
more » ... ses or traits. One of the functional mechanisms of missense SNPs is that they may affect PTMs and leads to a protein dysfunction and its downstream signaling pathway disorder. Here, we constructed a database named AWESOME (A Website Exhibits SNP On Modification Event, http://www.awesome-hust.com), which is an interactive web-based analysis tool that systematically evaluates the role of SNPs on nearly all kinds of PTMs based on 20 available tools. We also provided a well-designed scoring system to compare the performance of different PTM prediction tools and help users to get a better interpretation of results. Users can search SNPs, genes or position of interest, filter with specific modifications or prediction methods, to get a comprehensive PTM change induced by SNPs. In summary, our database provides a convenient way to detect PTM-related SNPs, which may potentially be pathogenic factors or therapeutic targets.
doi:10.1093/nar/gky821 pmid:30215764 fatcat:642wsfs5vfei3d54yvtijycqm4