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Flint, MI experienced two outbreaks of Legionnaires' Disease (LD) during the summers of 2014 and 2015, coinciding with use of Flint River as a drinking water source without corrosion control. Using simulated distribution systems (SDSs) followed by stagnant simulated premise (i.e., building) plumbing reactors (SPPRs) containing cross-linked polyethylene (PEX) or copper pipe, we reproduced trends in water chemistry and Legionella proliferation observed in the field when Flint River versus Detroitdoi:10.3390/pathogens9090730 pmid:32899686 fatcat:rca35tbxmzg7flkl5ufzyk5pqa